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Black phosphorus/silk fibroin films hamper filamentous and invasive growth of . | LitMetric

AI Article Synopsis

  • The study explored how mixing black phosphorus (BP) with silk fibroin (SF) alters the surface stiffness of the material, affecting the growth and shape of cells.
  • Using advanced spectroscopy techniques, researchers confirmed changes in the thickness of BP flakes and the formation of β-sheet structures, which enhanced the material's stiffness.
  • Findings indicate that these modifications reduce cell vitality and their ability to form biofilms, suggesting potential for designing better coatings for biomedical uses.

Article Abstract

The ability of fungi and bacteria to form biofilms on surfaces poses a serious threat to health and a problem in industrial settings. In this work, we investigated how the surface stiffness of silk fibroin (SF) films is modulated by the interaction with black phosphorus (BP) flakes, quantifying the morphogenesis of cells. Raman and infrared (IR) spectroscopies, along with scanning transmission electron microscopy, allowed us to quantify the thickness and diameter of BP flakes dispersed in the SF matrix (, 5.5 nm in thickness and 20 μm in diameter), as well as an increase in beta-sheet secondary structures, resulting in the mesoscopic formation of a globular and nanofibrous surface. The formation of β-sheet crystals in the SF/BP film was correlated with a higher surface stiffness, influencing the shape of cells and suppressing their filamentous growth. Raman spectroscopy analysis ultimately suggests an overall reduction in cell vitality and filmogenic capability of cells grown on fibroin-based films containing BP. Our results suggest that the conformational properties of SF can be suitably tuned to design optimized bioselective coatings for biomedical applications.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632600PMC
http://dx.doi.org/10.1039/d4ra05126bDOI Listing

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