AI Article Synopsis
- - This study investigates how heritability affects hearing acuity across different frequencies by analyzing 34 family pedigrees from the Utah CEPH, using genomic sequencing and audiometric tests.
- - Results show that heritability decreases as frequency increases, with estimates going from 51% at 250Hz to 30% at 8000Hz, indicating stronger genetic influence at lower frequencies.
- - The genetic correlation between hearing acuity at similar frequencies is high (e.g., 0.80 between 250Hz and 500Hz), while correlations drop significantly between distant frequencies (0.21 between 250Hz and 8000Hz), highlighting the nuanced genetic factors affecting hearing abilities.
Article Abstract
This study presents a frequency-specific, pedigree-based assessment of hearing acuity heritability. We analyzed 34 Utah Centre d'Etude du Polymorphisme Humain (CEPH) pedigrees comprising 464 individuals, using whole-genome sequencing (WGS) and audiometric evaluations. Our analysis reveals a general decline in narrow-sense heritability as frequency increases. When calculated using the Sequential Oligogenic Linkage Analysis Routines (SOLAR) software package, narrow-sense heritability estimates drop from 51% at 250Hz to 30% at 8000Hz. Genetic correlations (Rho(G)), the degree to which genetic variation in one trait correlates with another, are higher for hearing acuity at similar frequencies. For example, Rho(G) between 250Hz and 500Hz is 0.80, and Rho(G) between 6000Hz and 8000Hz is 0.91. In contrast, frequencies distant from each other exhibit decreased Rho(G) with a genetic correlation of only 0.21 for hearing acuity at frequencies 250Hz and 8000Hz. This assessment of the genetics underlying hearing acuity in a family-based design provides new details of genetic factors influencing hearing acuity in a frequency-specific approach.
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| http://dx.doi.org/10.1093/g3journal/jkae292 | DOI Listing |
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