Palladium-Catalyzed Dual C-H Arylation/Cyclization Reaction of Iodoferrocenes with -Bromobenzamides for the Construction of Arylated Isoquinolone-Fused Ferrocenes.

We reported a palladium/norbornene-catalyzed dual intermolecular C-H arylation/intramolecular cyclization reaction of iodoferrocenes with -bromobenzamides, enabling the formation of arylated isoquinolone-fused ferrocenes in a straightforward and effective manner. This method has a broad substrate scope and good functional group compatibility, while the gram-scale reaction demonstrates the practicality of this method.