AI Article Synopsis
- Researchers developed a new method for breaking S-S bonds using a Se-S dynamic exchange reaction with NaSe-disulfide.
- This method was successfully applied to create benzothiazole derivatives, showing effective bond cleavage with lower amounts of the reagent needed.
- The findings suggest that this metal selenide-disulfide interchange could be a useful technique for synthesizing various sulfur-containing compounds.
Article Abstract
We report a Se-S dynamic exchange reaction as a methodology for highly efficient S-S bond cleavage. In this study, a NaSe-disulfide dynamic exchange reaction has been demonstrated for the first time and the strategy has been employed in the preparation of benzothiazole derivatives, demonstrating highly efficient S-S bond cleavage, lowered dosage of the S-S bond cleaving reagent, good tolerance toward various substituents and excellent yields. It is envisaged that the concept of metal selenide-disulfide dynamic interchange reaction is a general avenue for synthesizing sulfur-containing heterocycles.
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| http://dx.doi.org/10.1039/d4ob01725k | DOI Listing |
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