Alzheimer's disease is a degenerative neurological condition resulting in brain cell death and brain tissue loss. Most importantly, memory-related brain cells are permanently harmed due to this condition. Alzheimer's disease diagnosis is a challenging task due to its high discriminative feature representation for classification using traditional machine learning (ML) methods. These challenges exist due to similar brain processes and pixel intensities. To overcome the above mentioned drawbacks, hybrid feature extraction techniques such as Gray Level Run Length Matrix (GLRLM), Gabor wavelet transform and Local Energy-based Shape Histogram (LESH) are used. In this designed model, Alzheimer's disease is predicted using brain MRI. At first, the collected magnetic resonance imaging (MRI) of the brain are resized and enhanced using the image resizing and BW-net technique. Features from these enhanced images are extracted using the GLRLM, Gabor wavelet transform and LESH techniques for shape, texture and edge of the brain MRI. Then, the extracted features are optimally selected using the SEAGULL optimization technique. These optimally selected features are trained using the modified DNN for predicting Alzheimer's disease. Performance metrics for proposed and existing models are studied and contrasted in order to assess the planned model. For the proposed model, 91%, 2%, 98% and 97% are performance metrics that were reached in aspects of precision, error, accuracy and recall. Thus, designed Alzheimer's disease prediction using modified DNN with optimal feature selection based on seagull optimization performs better and accurately predicts Alzheimer's disease.
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http://dx.doi.org/10.1007/s10278-024-01262-z | DOI Listing |
Sci Rep
December 2024
Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands.
The aetiology of Alzheimer's disease (AD) and Parkinson's disease (PD) are unknown and tend to manifest at a late stage in life; even though these neurodegenerative diseases are caused by different affected proteins, they are both characterized by neuroinflammation. Links between bacterial and viral infection and AD/PD has been suggested in several studies, however, few have attempted to establish a link between fungal infection and AD/PD. In this study we adopted a nanopore-based sequencing approach to characterise the presence or absence of fungal genera in both human brain tissue and cerebrospinal fluid (CSF).
View Article and Find Full Text PDFNat Commun
December 2024
Department of Theory and Bio-Systems, Max Planck Institute of Colloids and Interfaces, 14476, Potsdam, Germany.
Neurodegeneration in Huntington's disease (HD) is accompanied by the aggregation of fragments of the mutant huntingtin protein, a biomarker of disease progression. A particular pathogenic role has been attributed to the aggregation-prone huntingtin exon 1 (HTTex1), generated by aberrant splicing or proteolysis, and containing the expanded polyglutamine (polyQ) segment. Unlike amyloid fibrils from Parkinson's and Alzheimer's diseases, the atomic-level structure of HTTex1 fibrils has remained unknown, limiting diagnostic and treatment efforts.
View Article and Find Full Text PDFNat Commun
December 2024
Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Impaired muscle mitochondrial oxidative capacity is associated with future cognitive impairment, and higher levels of PET and blood biomarkers of Alzheimer's disease and neurodegeneration. Here, we examine its associations with up to over a decade-long changes in brain atrophy and microstructure. Higher in vivo skeletal muscle oxidative capacity via MR spectroscopy (post-exercise recovery rate, k) is associated with less ventricular enlargement and brain aging progression, and less atrophy in specific regions, notably primary sensorimotor cortex, temporal white and gray matter, thalamus, occipital areas, cingulate cortex, and cerebellum white matter.
View Article and Find Full Text PDFJ Neuroimaging
December 2024
Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Background And Purpose: In idiopathic normal pressure hydrocephalus (iNPH) patients, cerebrospinal fluid (CSF) flow is typically evaluated with a cardiac-gated two-dimensional (2D) phase-contrast (PC) MRI through the cerebral aqueduct. This approach is limited by the evaluation of a single location and does not account for respiration effects on flow. In this study, we quantified the cardiac and respiratory contributions to CSF movement at multiple intracranial locations using a real-time 2D PC-MRI and evaluated the diagnostic value of CSF dynamics biomarkers in classifying iNPH patients.
View Article and Find Full Text PDFBackground: Atrial fibrillation (AF) is associated with cognitive decline. Use of oral anticoagulant (OAC) medications offers a lower risk of dementia, but it is unclear whether differences exist between types of OAC agents.
Objective: This was a secondary analysis to explore whether the progression from normal cognition to mild cognitive impairment to dementia differs between adults with AF on warfarin versus non-vitamin K inhibitors medications (NOACs) using data extracted from the National Alzheimer's Coordinating Center clinical case series.
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