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Exhaled breath metabolites reveal postmenopausal gut-bone cross-talk and non-invasive markers for osteoporosis.
Commun Med (Lond)
December 2024
Rostock Medical Breath Research Analytics and Technologies (ROMBAT), Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Rostock University Medical Center, Rostock, Germany.
Background: Menopause driven decline in estrogen exposes women to risk of osteoporosis. Detection of early onset and silent progression are keys to prevent fractures and associated burdens.
Methods: In a discovery cohort of 120 postmenopausal women, we combined repeated quantitative pulse-echo ultrasonography of bone, assessment of grip strength and serum bone markers with mass-spectrometric analysis of exhaled metabolites to find breath volatile markers and quantitative cutoff levels for osteoporosis.
FXYD1 was identified as a hub gene in recurrent miscarriage and involved in decidualization via regulating Na/K-ATPase activity.
J Assist Reprod Genet
December 2024
Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of ReproductionRegulation,Shanghai Institute for Biomedical and Pharmaceutical Technologies,Medical School, Fudan University, Shanghai, 200237, China.
Purpose: Recurrent miscarriage (RM) is a distressing and complicated adverse pregnancy outcome. It is commonly recognized that insufficient decidualization could result in RM, but the molecular mechanisms of decidual impairment are still not fully understood. Thus, this study aimed to identify novel key genes potentially involved in RM and explore their roles played in endometrial decidualization.
View Article and Find Full Text PDFAdvance Glycation End Products Inhibition by Peel Extract; Characterization, LCMS-QTOF Analysis, and Biological Evaluation.
Food Sci Nutr
December 2024
NPRL, Department of Pharmacognosy, Faculty of Pharmacy Gomal University Dera Ismail Khan Khyber Pakhtunkhwa Pakistan.
Advance glycation end products (AGEs) are the main reason for diabetic complications. Persistent hyperglycemia and non-enzymatic glycation increase the rate of AGEs formation. Natural functional food-based approaches are mainly under investigation these days to discover new treatment options.
View Article and Find Full Text PDFIdentification of circulating risk biomarkers for cognitive decline in a large community-based population in Chongqing China.
Alzheimers Dement
December 2024
Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Introduction: This study aims to investigate the relationship between blood-based pathologies and established risk factors for cognitive decline in the community-based population of Chongqing, a region with significant aging.
Methods: A total of 26,554 residents aged 50 years and older were recruited. Multinomial logistic regression models were applied to assess the risk factors of cognition levels.
Proteomic and metabolomic exploration in relapse acute myeloid leukemia bone marrow supernatant combined with genetic characteristics.
BMC Cancer
December 2024
Department of Laboratory Medicine, Chongqing General Hospital, Chongqing University, No.118, Xingguang Avenue, Liangjiang New Area, Chongqing, 401147, China.
Object: Aim to investigate the multi-omic characteristics of the bone marrow supernatant of relapsed acute myeloid leukemia (AML) and search for proteins and metabolites associated with relapse.
Methods: A total of 40 bone marrow supernatant from 7 patients with relapsed AML and 33 patients with non-relapsed AML were collected for proteomics and metabonomics analysis. Unsupervised clustering was used to discover the characteristics of proteins and metabolites.
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