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Genetic prediction of blood metabolites mediating the relationship between gut microbiota and postpartum depression: A mendelian randomization study.
J Psychiatr Res
December 2024
Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Background: Observational studies have suggested an association between gut microbiota(GM) and postpartum depression (PPD). However, the causal relationship remains unclear, and the role of blood metabolites in this association remains elusive.
Methods: This study firstly elucidated the causal relationship among 196 GM taxa, 224 blood metabolites, and PPD from a genetic perspective, employing two-sample Mendelian randomization (MR).
Exploring the causal relationship between inflammatory cytokines and myasthenia gravis: A two-way Mendelian randomization study.
Cytokine
December 2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. Electronic address:
Background: Based on previous research, it is well-established that myasthenia gravis (MG) is linked to chronic inflammation. However, the exact nature of the relationship between inflammatory factors and the development of MG remains unclear. Consequently, the objective of this study is to explore whether alterations in the levels of inflammatory factors, as influenced by genetic factors, are associated with the occurrence of MG.
View Article and Find Full Text PDFNovoRank: Refinement for Peptide Sequencing Based on Spectral Clustering and Deep Learning.
J Proteome Res
December 2024
Department of Artificial Intelligence, Hanyang University, Seoul 04763, Republic of Korea.
peptide sequencing is a valuable technique in mass-spectrometry-based proteomics, as it deduces peptide sequences directly from tandem mass spectra without relying on sequence databases. This database-independent method, however, relies solely on imperfect scoring functions that often lead to erroneous peptide identifications. To boost correct identification, we present NovoRank, a postprocessing tool that employs spectral clustering and machine learning to assign more plausible peptide sequences to spectra.
View Article and Find Full Text PDFA tension system for angular correction of bent intramedullary nails: in vitro analysis.
Eur J Orthop Surg Traumatol
December 2024
Department of Orthopedics and Trauma, Universidade Federal Fluminense (UFF), Niterói, Rio de Janeiro, Brazil.
Purpose: Although several techniques have been described for bent intramedullary nail removal, there is no universally accepted strategy. We hypothesized that a device based on the action principle of a three-point bend fixture could facilitate extraction of bent intramedullary nails; this paper describes its design and experimental testing.
Methods: Five large synthetic left femurs and five steel intramedullary nails were used.
A generative adversarial network for multiple reads reconstruction in DNA storage.
Sci Rep
December 2024
Institution of Computational Science and Technology, Guangzhou University, Guangzhou, China.
DNA storage is widely considered as a promising solution to the data explosion problem. However, the synthesis, PCR and sequencing processes usually result in erroneous reads involving base insertions, deletions, and substitutions. Specially this situation is even more serious in the 3rd generation of sequencing technologies.
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