Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Quercetin, a natural flavonoid, is well-proven for anticancer properties in a variety of cancers. Quercetin's anticancer action is driven by its anti-inflammatory and antioxidant properties. It inhibits pro-inflammatory cytokines (e.g., TNF-α, IL-6) and suppresses NF-κB and COX-2, reducing tumor growth. Its antioxidant activity neutralizes reactive oxygen species (ROS), preventing oxidative damage that can lead to cancer. However, quercetin faces challenges such as poor solubility, bioavailability, instability, low skin penetration, rapid metabolism, and potential systemic toxicity at high doses, which limit its therapeutic application. Nanocarrier systems such as liposomes, polymeric nanoparticles (PLGA-based), solid lipid nanoparticles (SLNs), and nanoemulsions have been developed to address these issues. These formulations enhance quercetin's penetration, stability, and bioavailability, improving its effectiveness against skin cancers by promoting controlled release and targeted delivery. Nanocarriers offer a promising solution to overcome these limitations and enhance its anticancer potential.
Download full-text PDF |
Source |
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http://dx.doi.org/10.2174/0122117385332427241112034005 | DOI Listing |
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