AI Article Synopsis
- Many existing fluorescent calcium sensors are affected by changes in pH, impacting their performance.
- Researchers developed a new calcium sensor that uses diacylated 1,10-diaza-18-crown-6, which is sensitive to low levels of calcium and can work in water.
- However, this sensor struggles with selecting calcium over other divalent cations and still shows pH sensitivity in acidic conditions, with insights provided on how its structure relates to these characteristics.
Article Abstract
The performance of many known fluorescent sensors for Ca is pH-dependent. We set out to address this by preparing a novel calcium sensor based on diacylated 1,10-diaza-18-crown-6 and containing no basic centres. The sensor is sensitive to sub-millimolar levels of Ca and partially tolerant of an aqueous environment. However, it suffers from a lack of selectivity over some other divalent cations, and retained pH sensitivity in the acidic range. The relations between these properties and the sensor's structure are discussed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627183 | PMC |
| http://dx.doi.org/10.1002/ansa.202400034 | DOI Listing |
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