Background: Reference centiles describing gross motor function in children with cerebral palsy (CP) are used in clinical and research settings to guide treatments and evaluate interventions. However, it is unknown how existing references generalize to populations in novel settings.
Aims: The aim of this study is to evaluate the cross-sectional and longitudinal performance of three reference centiles to describe the motor function of children with CP aged 2-12 years at a large urban US pediatric hospital through a retrospective observational study.
Methods: and Procedures: We assessed cross-sectional performance by ranking our clinical population by quartile distributions described by the references. We assessed longitudinal performance by analyzing the distribution of prediction errors and correlations between predictions and observed scores.
Outcomes And Results: For cross-sectional distribution, the reference centiles by Hanna more closely described our population than those by Duran. For longitudinal progression, prediction error was less than 6 GMFM points for most records at 24-, 12-, and 6-month time scales for all three sets of reference centiles, but higher at a 48-month time scale. Prediction errors increased at younger ages and higher motor ability.
Conclusions And Implications: Despite differences in cross-sectional performance, all three reference centiles achieved similar longitudinal performance and are sufficient for most clinical and research uses. Caution should be used when applying these curves to locations with different standards of care.
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http://dx.doi.org/10.1016/j.heliyon.2024.e40615 | DOI Listing |
J Pediatr Urol
December 2024
Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi, India. Electronic address:
Am J Obstet Gynecol
December 2024
department of Obstetrics and Gynaecology, University Medical Center Utrecht, Lundlaan 6, 3584 EA, Utrecht, and department of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, the Netherlands. Electronic address:
Background: Early-onset fetal growth restriction as consequence of placental insufficiency frequently requires iatrogenic, preterm birth. Administration of antenatal corticosteroids reduces risks of neonatal morbidity and mortality following preterm birth and is most beneficial if the neonate is delivered within two weeks following treatment. International guidelines on fetal growth restriction pregnancies do not provide directives regarding the timing of antenatal corticosteroids, resulting in practice variation.
View Article and Find Full Text PDFJ Paediatr Child Health
December 2024
Department of Nutrition and Dietetics, Karadeniz Technical University, Trabzon, Turkey.
Aim: There is a need for population-based reference values of handgrip strength, which is an objective measurement reflecting muscle status, in the paediatric population and there is limited data on the prognostic importance of handgrip strength. The aim of the study was to establish reference percentiles for handgrip strength in healthy Turkish children and to investigate the relationship between handgrip strength and clinical outcomes in hospitalised children.
Methods: A total of 1437 healthy children and 103 hospitalised children aged 6-16 years were included in this cross-sectional study.
Heliyon
December 2024
Division of Rehabilitation Medicine, Children's Hospital of Philadelphia, Philadelphia, USA.
Background: Reference centiles describing gross motor function in children with cerebral palsy (CP) are used in clinical and research settings to guide treatments and evaluate interventions. However, it is unknown how existing references generalize to populations in novel settings.
Aims: The aim of this study is to evaluate the cross-sectional and longitudinal performance of three reference centiles to describe the motor function of children with CP aged 2-12 years at a large urban US pediatric hospital through a retrospective observational study.
Sci Rep
November 2024
SYSNAV, Paris, France.
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