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Mitigating Paxlovid™-induced drug‒drug interaction toxicity: an insight. | LitMetric

Mitigating Paxlovid™-induced drug‒drug interaction toxicity: an insight.

Front Pharmacol

Department of Chemistry, National Dong Hwa University, Hualien, Taiwan.

Published: November 2024

AI Article Synopsis

Article Abstract

The clinical drug-drug interaction side-effects of Ritonavir, an ingredient in Paxlovid™, have been documented, highlighting the need to explore alternative administration methods for Nirmatrelvir, another drug in the Paxlovid™ combination. In this study, the skin permeability potential of Nirmatrelvir was assessed using various models. The prediction results suggest that Nirmatrelvir could be administrated via the transdermal route, offering a promising avenue to enhance the efficacy of anti-COVID-19 agents.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628247PMC
http://dx.doi.org/10.3389/fphar.2024.1496630DOI Listing

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