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| http://dx.doi.org/10.3389/fnins.2024.1522600 | DOI Listing |
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Dealing With Environmental Stress: Why Is It Time to Move Towards a New Approach to Depression?
Cureus
November 2024
Health and Technology, Stress Management and Therapy Clinic, Naples, ITA.
Depression is a complex mental health condition characterized by persistent sadness, loss of interest, and a range of cognitive, emotional, and behavioral symptoms. It can be acute or chronic and is often influenced by a combination of genetic, biological, psychological, and social factors. According to transnational estimates of prevalence, depressive symptoms represent the most concerning challenge to mental health across cultures and beyond geographical borders.
View Article and Find Full Text PDFMoving the Boundaries of the Diagnosis of Unexplained Sudden Cardiac Arrest and Sudden Cardiac Death in the Young.
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Clinical Associate Clinical Genomics Lab Director, Labcorp Genetics Inc. (formerly Invitae Corporation), 1400 16th Street, San Francisco, CA 94103. Electronic address:
Evaluation in Acute Type B Aortic Dissection Management and Outcomes: The IRAD experience and beyond.
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Cardiovascular Center, University of Michigan, Ann Arbor, Mich.
Protein shapeshifting in necroptotic cell death signaling.
Trends Biochem Sci
December 2024
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia. Electronic address:
Necroptosis is a mode of programmed cell death executed by the mixed lineage kinase domain-like (MLKL) pseudokinase following its activation by the upstream receptor-interacting protein kinase-3 (RIPK3), subsequent to activation of death, Toll-like, and pathogen receptors. The pathway originates in innate immunity, although interest has surged in therapeutically targeting necroptosis owing to its dysregulation in inflammatory diseases. Here, we explore how protein conformation and higher order assembly of the pathway effectors - Z-DNA-binding protein-1 (ZBP1), RIPK1, RIPK3, and MLKL - can be modulated by post-translational modifications, such as phosphorylation, ubiquitylation, and lipidation, and intermolecular interactions to tune activities and modulate necroptotic signaling flux.
View Article and Find Full Text PDFRole of Altmetric Attention Scores in Evaluating the Influence of Spine Surgery Research.
Clin Spine Surg
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Department of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, Philadelphia, PA.
Study Design: Retrospective cohort.
Objective: To analyze the annual trends in the most prevalent topics, journals, and geographic regions of the top 100 spine surgery articles, as determined by altmetric attention scores (AASs). We also describe the relationship between AAS and traditional article metrics.
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