Institute of Analytical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China.
Published: December 2024
AI Article Synopsis
Article Abstract
The escalating needs in information protection underscore the urgency of developing advanced encryption strategies. Herein we report a novel chemical approach that enables information encryption by on-paper electrochemiluminescence (ECL). Dendritic porous silica nanospheres modified with polyetherimide and bovine serum albumin were prepared as the chemical ink to write the secret message on a paper. Attaching the paper to an electrode, immersing it in a solution containing tris(2,2'-bipyridyl)ruthenium (Ru(bpy) ) and then applying a suitable voltage, a remote "catalytic route" electrochemical reaction produces ECL that functions as the key to decrypt and visualize the message by imaging. In addition, proteins can be also used as the biological ink to write the secret message, which is then decrypted by a combined use of immunochemistry and ECL imaging as two keys. We believe the ECL-based strategy holds great promise in high-safety and multilevel information encryption, as it is protected not only by encoding, like conventional invisible inks, but also by the unique ECL decoding approach.
The escalating needs in information protection underscore the urgency of developing advanced encryption strategies. Herein we report a novel chemical approach that enables information encryption by on-paper electrochemiluminescence (ECL). Dendritic porous silica nanospheres modified with polyetherimide and bovine serum albumin were prepared as the chemical ink to write the secret message on a paper.
Precise diagnosis and effective therapy of the tumor microenvironment (TME) remains a challenge. Fluorescence tracers for monitoring primary tumors are currently reported; however, they face challenges in accurately delineating tumors in real-time during surgery, including interference from the background and insufficient accumulation of imaging reagents at tumor sites. Additionally, although the natural product podophyllotoxin (PPT) had potent and broad anti-tumor activity, the poor tumor target specificity and high toxicity of PPT extremely limited its clinical application.
Background And Objectives: It is controversial whether hospital care mitigated or exacerbated population level racial and ethnic disparities in COVID-19 mortality. To begin answering that question, this study analyzed variations in COVID-19 hospital mortality in Illinois by patient race and ethnicity and by hospital characteristics, while providing an estimate of hospital-level variation in COVID-19 mortality.
Method: This is a retrospective cohort study based on hospital administrative data for adult patients with COVID-19 discharged from acute care, non-federal Illinois hospitals from April 1, 2020 through June 30, 2021.
Client-Server (C/S) application is always used in the existing Human Resource Management System (HRMS) as the system architecture, which has the problems of complex maintenance and poor compatibility; and cannot use professional database and development system, making the system development difficult and the data security low. To solve the above problems, the overall demand is analyzed, as well as feasibility and key technologies of the enterprise HRMS system. Then a HRMS is designed and developed, based on the user's key functional requirements and related technologies, which is reasonable and easy to maintain.
Background: Easy-to-access tools have been demonstrated to improve evidence-based practice (EBP) competences among nursing students. However, students' perception of access to EBP tools (e.g.
