Background: For a comprehensive evaluation and due to the inconsistent results of previous studies, we performed this meta-analysis with the aim of vitamin C effect on breast cancer and prostate cancer and colorectal cancer.

Methods: PubMed, Scopus and Web of Science were searched to identify studies on the association between vitamin C and breast cancer, prostate cancer and colorectal cancer through September 11, 2023. The pooled RR and the 95% confidence intervals were used to measure the association between vitamin C and breast cancer, prostate cancer and colorectal cancer by assuming a random effects meta-analytic model. Newcastle-Ottawa scale was used for quality appraisal.

Results: A total of 69 studies were included. The pooled RR for the association between vitamin C (dietary) and breast cancer in the cohort study was 0.99 [95% CI: 0.95, 1.03], but the pooled RR in the case-control study was 0.72 [95% CI: 0.60, 0.85]. No association was found between vitamin E (supplemental, total intake) and breast cancer in studies. The pooled RR for the association between vitamin C (dietary) and prostate cancer was 0.88 [95% CI: 0.77, 1.00], which represents a decrease in prostate cancer. No association was found between vitamin C (supplemental) and prostate cancer in studies. The pooled RR for the association between vitamin C (dietary) and colorectal cancer was 0.55 [95% CI: 0.42, 0.73], which represents a decrease in colorectal cancer.

Conclusion: Our analysis shows an inverse significant relationship between vitamin C (dietary) and breast cancer in the case-control study. Also between vitamin C (dietary) and prostate cancer and colorectal cancer in studies, which represents a decrease in cancers.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clnesp.2024.12.001DOI Listing

Publication Analysis

Top Keywords

association vitamin
32
prostate cancer
32
breast cancer
28
cancer
20
cancer colorectal
20
colorectal cancer
20
vitamin dietary
20
vitamin breast
16
cancer prostate
16
pooled association
12

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!