AI Article Synopsis
- - Polymyalgia rheumatica (PMR) is an inflammatory disorder marked by muscle pain and stiffness, mainly affecting the hip and shoulder areas, with high levels of CRP and ESR, but its exact causes are still unclear.
- - The report discusses three PMR patients who didn't respond well to standard treatments, presenting common symptoms such as muscle pain and weakness, and elevated CRP levels without increased creatine kinase.
- - Examination of muscle samples from these patients revealed signs of vasculitis, suggesting that muscular limited vasculitis (MLV) could be a potential underlying issue in these difficult-to-treat PMR cases.
Article Abstract
Polymyalgia rheumatica (PMR) is a common inflammatory disorder characterized by myalgia/stiffness in proximal hip and shoulder girdle, elevated C reactive protein (CRP) and erythrocyte sedimentation rate (ESR), but its pathogenesis is not fully elucidated. We report three cases of PMR who do not respond adequately to standard treatment. Those patients had typical symptoms of myalgia and muscle weakness, with elevated CRP in absence of creatine kinase elevation. Muscle specimen showed the findings of vasculitis in all cases, therefore muscular limited vasculitis (MLV) may be an underlying pathology in PMR in those refractory cases.
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| http://dx.doi.org/10.1093/mrcr/rxae072 | DOI Listing |
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