We show that human myxovirus resistance protein 1 (MxA) suppresses replication of highly pathogenic avian influenza A(H5N1) viruses isolated from mammals in vitro and in MxA-transgenic mice. However, H5N1 can evade MxA restriction through replacement of individual viral polymerase complex components from a human-adapted MxA-resistant strain in vitro.
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| http://dx.doi.org/10.3201/eid3101.241236 | DOI Listing |
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11682815 | PMC |
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