AI Article Synopsis
- This study investigates the genetic link between emotional disorders (like worry, anxiety, and depression) and temporomandibular disorder (TMD)-related pain using two-sample Mendelian randomization analysis.
- It utilizes single-nucleotide polymorphisms (SNPs) from large genomic databases (UK Biobank and FinnGen) to analyze the relationship, emphasizing the reliability of results through various statistical methods.
- The findings indicate a significant association, showing that emotional disorders correlate with increased TMD-related pain, which could inform future treatment approaches and causal understanding.
Article Abstract
Objectives: This study aims to evaluate the genetic association between emotional disorders and TMD-related pain through two-sample Mendelian randomization analysis.
Design: Single-nucleotide polymorphisms (SNPs) related to emotional disorders (worry, nerves, or depression) were selected from genome-wide association studies (GWAS) from UK Biobank consortia, and related these to SNPs from FinnGen consortia. The inverse-variance weighted (IVW) was used as the primary effect estimate between emotional disorders and TMD-related pain, and various methods were applied to test the reliability and stability of the results, namely MR-Egger and weighted median.
Results: The Mendelian randomization analysis showed that there was a positive correlation between emotional disorders and TMD-related pain, including worry group (IVW odds ratio (OR) = 3.86, 95 % confidence interval (CI) = 1.67-8.91), nerves group (IVW OR = 11.20, 95 % CI=2.04-61.64) and depression group (IVW OR = 3.32, 95 % CI=1.24-8.90). MR-Egger intercept and MR-PRESSO global test did not suggest evidence of horizontal or directional pleiotropy. Cochran's Q test showed that there was no heterogeneity between instrumental variables.
Conclusions: This study provides genetic evidence that strengthens the connection between emotional disorders and TMD-related pain, which has important implications at the causal level as well as throughout the treatment process of TMD-related pain.
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| http://dx.doi.org/10.1016/j.archoralbio.2024.106150 | DOI Listing |
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