Determining an appropriate sample size in psychological experiments is a common challenge, requiring a balance between maximizing the chance of detecting a true effect (minimizing false negatives) and minimizing the risk of observing an effect where none exists (minimizing false positives). A recent study proposes using effect size stabilization, a form of optional stopping, to define sample size without increasing the risk of false positives. In effect size stabilization, researchers monitor the effect size of their samples throughout the sampling process and stop sampling when the effect no longer varies beyond predefined thresholds. This study aims to improve our understanding of effect size stabilization properties. Simulations involving effect size stabilization are presented, with parametric modulation of the true effect in the population and the strictness of the stabilization rule. As previously demonstrated, the results indicate that optional stopping based on effect-size stabilization consistently yields unbiased samples over the long run. However, simulations also reveal that effect size stabilization does not guarantee the detection of a true effect in the population. Consequently, researchers adopting effect size stabilization put themselves at risk of increasing type 2 error probability. Instead of using effect-size stabilization procedures for testing, researchers should use them to reach accurate parameter estimates.
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http://dx.doi.org/10.3758/s13428-024-02549-3 | DOI Listing |
Doping strategies have been recognized as effective approaches for developing cost-effective and durable catalysts with enhanced reactivity and selectivity in the electrochemical synthesis of value-added compounds directly from CO. However, the reaction mechanism and the specific roles of heteroatom doping, such as N doping, in advancing the CO reduction reaction are still controversial due to the lack of precise control of catalyst surface microenvironments. In this study, we investigated the effects of N doping on the performances for electrochemically converting CO to CO over Ni@NCNT/graphene hybrid structured catalysts (Ni@NCNT/Gr).
View Article and Find Full Text PDFACS Sustain Chem Eng
January 2025
Department of Chemistry and Biochemistry, Rowan University, Glassboro, New Jersey 08028, United States.
Ethyl cellulose (EC) is a biocompatible, renewable, and recyclable material with diverse sources, making it an attractive candidate for industrial applications. Electrospinning has gained significant attention for the production of EC fibers. However, conventional electrospinning methods face challenges such as bead formation, low yield, and the absence of porous internal structures, limiting both the functional performance and scalability.
View Article and Find Full Text PDFEur J Trauma Emerg Surg
January 2025
Julius Wolff Institute, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Background: Flail chest (FC) injuries are segmental osseous injuries of the thorax that typically result from high-energy blunt trauma and regularly occur in multiple trauma (MT) patients. FC injuries are associated with paradoxical chest wall movements and, thus, have a high risk of respiratory insufficiency or even death. An increasing number of studies recommend an early surgical stabilization of FC injuries, but a definite trigger that would indicate surgery has, thus far, not been identified.
View Article and Find Full Text PDFNanoscale
January 2025
Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Macau SAR 999078, China.
Two-dimensional organic-inorganic perovskites have garnered extensive interest owing to their unique structure and optoelectronic performance. However, their loose structures complicate the elucidation of mechanisms and tend to cause uncertainty and variations in experimental and calculated results. This can generally be rooted in dynamically swinging spacer molecules through two mechanisms: one is the intrinsic geometric steric effect, and the other is related to the electronic effect orbital overlapping and electronic screening.
View Article and Find Full Text PDFCurr Drug Deliv
January 2025
Department of Biopharmaceutical, Lishui University, 1 Xueyuan Road, Lishui, 323000, China.
Background: Overcoming the poor aqueous solubility of small-molecule drugs is a major challenge in developing clinical pharmaceuticals. Felodipine (FLDP), an L-type calcium calcium channel blocker, is a poorly water-soluble drug.
Objectives: The study aimed to explore the potential applications of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (Soluplus) stabilized amorphous dispersions for augmenting the oral delivery of poorly water-soluble drugs.
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