The relationship between the scientific method and clinical practice was discussed in an earlier column. Another column described the application of analog scales to clinical practice. This column will discuss how the combination of these 2 strategies can be used to increase the efficiency and completeness of outpatient psychiatric management.
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Effect of hay type and breed on the fattening, centesimal and fatty acid composition of Nigerian sheep.
Trop Anim Health Prod
December 2024
National Animal Production Research Institute, Ahmadu Bello University, P.M.B. 1096, Shika - Zaria, Nigeria.
This study aimed to evaluate the intake, performance, quality, and fatty acids (FA) composition of the meat of three Nigerian sheep breeds (Balami, Uda, and Yankasa) fed two different hays, Brachiaria decumbens or Digitaria smutsii. A total of sixty sheep, twenty from each breed, Balami, Uda, and Yankasa, were used, with average body weights of 24.7 ± 3.
View Article and Find Full Text PDFPre-diabetes virtual health management community (VHMC) intervention and group interaction management model in China: a randomised clinical trial protocol.
BMJ Open
December 2024
Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology & Guangzhou Municipal Key Laboratory of Mechanistic and Translational Obesity Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Introduction: Individuals with pre-diabetes are at high risk for developing type 2 diabetes mellitus (T2DM), which makes them prone to serious complications such as stroke, kidney failure, blindness and lower-limb amputation. Pre-diabetes can be reversed, and lifestyle modification is considered the best intervention method for diabetes prevention. However, it is difficult for individuals with pre-diabetes to maintain a long-term modified healthy lifestyle owing to psychological burnout in daily management over time due to poor adherence.
View Article and Find Full Text PDFEffect of needle size on outcomes of vacuum-assisted excision of breast lesions. A randomized controlled trial.
Eur J Radiol
December 2024
Department of Radiology, Karolinska University Hospital, Stockholm, Sweden; Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Background: Utilizing a larger needle-size instead of a smaller one in vacuum-assisted excision of breast lesions might enhance the effectiveness of the method. We conducted a clinical trial to investigate the effects of needle size 7G compared to 10G regarding excision completeness and procedural efficiency.
Materials And Methods: In this prospective, single-blinded, randomized clinical trial, the patients were enrolled between November 2019 and August 2022.
Efficient visible-light-driven removal of persistent antibiotics and synthetic dyes from wastewater using an engineered 2D/2D BiMoO/NiAl-LDH S-scheme heterocatalyst with enhanced interfacial contact.
Environ Res
December 2024
School of Architecture, Civil, Environmental and Energy Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea. Electronic address:
Highly efficient photocatalysts for degrading persistent antibiotics and synthetic dye pollutants under visible light are crucial for sustainable environmental remediation. In this study, we engineered a novel BiMoO (BMO)/NiAl-LDH (layered double hydroxide) hybrid catalyst with a unique 2D/2D heterostructure, optimized for the visible-light-driven elimination of ciprofloxacin (CPF) and hazardous synthetic dyes such as rhodamine B and methylene blue. The optimized BMO-30/LDH hybrid demonstrated exceptional photocatalytic performance, achieving nearly complete degradation of CPF and synthetic dyes with high mineralization efficiency, surpassing many previously reported state-of-the-art photocatalysts.
View Article and Find Full Text PDFSynthesis and structural modification of the natural product Ivesinol to discover novel autophagy activators.
Eur J Med Chem
December 2024
Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400021, China. Electronic address:
Autophagy is a lysosome-dependent cellular degradation pathway that responds to a variety of environmental and cellular stresses, which is defective in aging and age-related diseases, therefore, targeting autophagy with small-molecule activators has potential therapeutic benefits. In this study, we successfully completed the first total synthesis of Ivesinol, an identified antibacterial natural product, and efficiently constructed a library of its analogs. To measure the effect of Ivesinol analogs on autophagic activity, we performed cell imaging-based screening approach, and observed that several Ivesinol analogs exhibited potent autophagy-regulating activity.
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