AI Article Synopsis
- Researchers are focused on creating new ionizable lipids for lipid nanoparticles (LNPs), essential for drug delivery systems.
- A new computational method has been developed to predict the apparent p value of these lipids when formulated in LNPs.
- This method was tested on lipid formulations in COVID-19 vaccines (COMIRNATY, Spikevax) and a siRNA therapy (Onpattro), including a variant called Lipid A used in COMIRNATY.
Article Abstract
Creating new ionizable lipids for use in lipid nanoparticles (LNPs) is an active field of research. One of the critical properties for selecting suitable ionizable lipids is the apparent p value of the lipid as formulated in an LNP. We have developed a structure-based, computational methodology for the prediction of the apparent p value of ionizable lipids within LNPs and have tested it using the lipid formulations in the mRNA LNP COVID-19 vaccines COMIRNATY and Spikevax, and the siRNA LNP therapeutic Onpattro. The calculation was also applied to Lipid A, a variant of the ionizable lipid used in COMIRNATY.
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| http://dx.doi.org/10.1021/acs.molpharmaceut.4c00426 | DOI Listing |
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