AI Article Synopsis
- Pterostilbene (PT) is a naturally occurring compound showing promise in treating various tumor diseases.
- Over the past 20 years, research has highlighted the antitumor effects of PT and its derivatives on multiple cancers, including colon, breast, liver, lung, and pancreatic cancers.
- The review also examines PT derivatives with better anti-tumor efficacy than PT itself and discusses structure-activity relationship (SAR) strategies for chemical modification and clinical applications of stilbene compounds.
Article Abstract
Pterostilbene (PT) is a naturally occurring small molecule stilbenoid that has garnered significant attention due to its potential therapeutic effects in tumor diseases. In this review, we conducted a comprehensive analysis of the antitumor effects of PT and its derivatives on various cancer types, including colon, breast, liver, lung, and pancreatic cancers in recent 20 years. We have succinctly summarized the PT derivatives that exhibit superior anti-tumor efficacy compared to PT. Additionally, we reviewed the potential structure-activity relationship (SAR) rules and clinical application methods to establish a foundation for chemical modification and clinical utilization of stilbene compounds.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11703139 | PMC |
| http://dx.doi.org/10.1080/17568919.2024.2435251 | DOI Listing |
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