Efficacy of Pyloshot in combination with standard four-drug antimicrobial treatment for eradication: A randomized clinical trial.

Background And Aim: The treatment for is considered to be a combination of several strict regimens, with patients' dissatisfaction and poor compliance. Probiotics are effective in patients' antibiotic regimens. This study investigated the efficacy of the Pyloshot probiotic in combination with standard four-drug therapy in patients with infection.

Methods: This is an interventional study. The study population consisted of patients with infection who were selected using the convenience sampling method and were randomly divided into two groups: (i) A or standard four-drug therapy (amoxicillin-clarithromycin-bismuth-pantoprazole) plus two placebo capsules (80 cases). (ii) B or Pyloshot group (standard four-drug therapy plus 2 Pyloshot probiotic capsules) (90 cases). Patients were followed up for 1 month after treatment completion. Eradication of was also assessed using the stool antigen test. Data were analyzed using SPSS (v.26) statistical software.

Results: Based on the results from the present study, the number of negative stool antigen tests in group A was less than that in group B, and no statistically significant relationship was found between eradication (based on stool antigen test) and the studied groups ( = 0.20). There was a statistically significant relationship between vomiting ( = 0.03), diarrhea ( = 0.04), constipation ( = 0.01), and headache ( = 0.04); vomiting and constipation were most frequent in the control group.

Conclusion: Based on the results of the present study, there was no significant difference between the effectiveness of treatment with Pyloshot probiotic and the standard four-drug therapy in patients with infection. However, the incidence of side effects was lower in the group treated with Pyloshot.