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Cancer continues to represent a substantial burden in terms of its morbidity and mortality, underscoring the imperative for the development of novel and efficacious treatment modalities. Recent advances in cancer immunotherapy have highlighted the importance of identifying tumour-specific antigens, which can assist the immune system in targeting malignant cells effectively. Phage display technology has emerged as an effective tool for the discovery of novel antigens through cDNA library screening, representing a significant advancement in the field of immunological research.
View Article and Find Full Text PDFRoutine Immunization Microplanning Challenges and Opportunities in Low- and Middle-Income Countries: A Mixed-Method Landscape Analysis.
Vaccines (Basel)
December 2024
PATH, Seattle, WA 98121, USA.
Background: Microplanning is widely recognized as a critical tool for improving immunization coverage and equity and is considered a core component of routine immunization. However, there is limited evidence on how microplans are developed and implemented and the effectiveness of microplanning. As such, this study sought to review the existing evidence on implementation and institutionalization of microplanning; identify strategies to improve microplanning; and document evidence on new approaches to microplanning, including digitally enhanced and integrated microplanning.
View Article and Find Full Text PDFLocal Lidocaine-Prilocaine for Immunisation in Infants.
Vaccines (Basel)
November 2024
Third Pediatric Discipline, Faculty of Medicine, Iuliu Hațieganu University of Medicine and Pharmacy, 400124 Cluj-Napoca, Romania.
: Lidocaine-prilocaine cream effectively reduces vaccination pain, improving vaccination adherence and advocating for its routine use in healthcare settings. : This review used PRISMA guidelines and the PICOT format to structure the analysis. The focus was on paediatric patients aged 0-12 months requiring intramuscular vaccinations, comparing the application of lidocaine-prilocaine cream to other interventions or no treatment.
View Article and Find Full Text PDFAdditive Manufacturing of a Frost-Detection Resistive Sensor for Optimizing Demand Defrost in Refrigeration Systems.
Sensors (Basel)
December 2024
Department of Electromechanical Engineering, University of Beira Interior, Rua Marquês d'Ávila e Bolama, 6201-001 Covilhã, Portugal.
This article presents the development of a resistive frost-detection sensor fabricated using Fused Filament Fabrication (FFF) with a conductive filament. This sensor was designed to enhance demand-defrost control in industrial refrigeration systems. Frost accumulation on evaporator surfaces blocks airflow and creates a thermal insulating barrier that reduces heat exchange efficiency, increasing energy consumption and operational costs.
View Article and Find Full Text PDFResearch on Tool Wear Monitoring Technology Based on Variational Mode Decomposition and Back Propagation Neural Network Model.
Sensors (Basel)
December 2024
School of Mechanical and Electrical Engineering, Shandong Jianzhu University, Jinan 250101, China.
Accurately predicting tool wear during the machining process not only saves machining time and improves efficiency but also ensures the production of good-quality parts and automation. This paper proposes a combined variational mode decomposition (VMD) and back propagation (BP) neural network model (VMD-BP), which maps spindle power to tool wear. The model is trained using both historical and real-time data.
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