Thiourea structures, known for their wide-ranging bioactivity, have significant potential in diabetes management. In this study, it was aimed to examine the antioxidant capacities of fluorophenyl thiourea derivative compounds and their inhibition studies on α-amylase and α-glycosidase enzyme activity. Antioxidant capacity was determined using Fe-Fe, FRAP, and Cu-Cu reducing analyses, DPPH· and ABTS· scavenging experiments. It was observed that fluorophenyl thiourea derivative compounds exhibited quite high antioxidant activity compared to standard antioxidants such as BHA, BHT, trolox, α-tocopherol, and ascorbic acid. Additionally, this study investigated the inhibitory effects of the analysis molecules on α-glycosidase and α-amylase, which are enzymes associated with diabetes. Among these derivative molecules, 4-fluorophenyl showed the highest inhibition on α-amylase (IC: 53.307 nM) and α-glycosidase (IC: 24.928 nM). These results highlight the potential of thiourea derivatives in enzyme inhibition and antioxidant therapy, making them promising candidates for diabetes management.
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