AI Article Synopsis
- - High levels of antibodies to interferon-gamma (IFN-γ) are linked to infections from intracellular pathogens, especially non-tuberculous mycobacteria (NTM) and tuberculosis (MTB).
- - The case study discusses a non-immunosuppressed patient who had both MTB infection and complications from NTM, which led to a severe condition called secondary hemophagocytic syndrome.
- - The report emphasizes the importance of recognizing this uncommon combination of infections to prevent misdiagnosis or unnecessary treatments for patients.
Article Abstract
High-titer antibodies to interferon-gamma (IFN-γ) are strongly correlated with infections caused by intracellular pathogens, particularly non-tuberculous mycobacteria and (TM). However, cases of concurrent infections with TM and (MTB) in non-immunosuppressed patients are extremely rare. We presented a clinical case of a patient with anti-IFN-γ autoantibodies who developed an MTB infection complicated by , which subsequently led to secondary hemophagocytic syndrome. This report aimed to raise clinicians' awareness of this rare association to minimize the risk of misdiagnosis and overdiagnosis.
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| http://dx.doi.org/10.3760/cma.j.cn112147-20240422-00214 | DOI Listing |
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