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A quality-by-design approach for optimizing the functionalization of gold nanoparticles onto the surface of doxorubicin-encapsulated liposomes. | LitMetric

A quality-by-design approach for optimizing the functionalization of gold nanoparticles onto the surface of doxorubicin-encapsulated liposomes.

Int J Pharm

Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Ciencias Farmacéuticas, Ciudad Universitaria, Haya de la Torre and Medina Allende, Science Building 2, Córdoba X5000HUA, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, UNITEFA, Córdoba X5000HUA, Argentina. Electronic address:

Published: December 2024

AI Article Synopsis

  • Stimulus-responsive liposomes (L) show promise for improving cancer treatments by efficiently encapsulating various drugs, particularly doxorubicin (Dox).
  • A quality-by-design (QbD) strategy was applied to optimize the surface functionalization of gold nanoparticles (AuNPs) on Dox-loaded liposomes, using a Taguchi design to evaluate factors like ratio, stirring, and temperature.
  • The resulting AuNPs-L-Dox nanoplatform allowed for controlled drug release under specific conditions and demonstrated increased anticancer effectiveness against ovarian cancer cells when exposed to light, emphasizing its potential in photothermal hyperthermia therapies.

Article Abstract

Stimulus-responsive liposomes (L) are increasingly recognized for their potential in enhancing therapies, especially in cancer nanomedicine, owing to their ability to encapsulate drugs of diverse properties efficiently. In this study, a quality-by-design (QbD) strategy was proposed to optimize the surface functionalization of gold nanoparticles (AuNPs) on doxorubicin (Dox)-loaded L intended for improving cancer treatment. Thin-film hydration and pH-gradient methods were applied for L preparation and Dox loading, respectively. Through a Taguchi design (L9), the AuNPs surface functionalization was optimized by studying variables such as L-Dox:AuNPs ratio, stirring time, temperature, and post-functionalization period, and their impact on various L properties including size, polydispersity, and loading efficiency. This approach allowed thedevelopment of an AuNPs-L-Dox nanoplatform capable of controlled Dox release under bio-relevant conditions and dual pH/photothermal responsiveness for triggering drug release. Upon light irradiation, the nanoplatform exhibited enhanced anticancer efficacy against ovarian cancer cells, showcasing its potential for photothermal hyperthermia therapies. Biocompatibility assessment in absence of irradiation against keratinocytes confirmed safety without increased drug cytotoxicity. This study underscores the effectiveness of the QbD approach in optimizing key parameters for the functionalization of L-Dox with AuNPs, highlighting the potential of this nanoplatform for triggered Dox delivery in cancer nanomedicine, particularly in photothermal hyperthermia therapies.

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Source
http://dx.doi.org/10.1016/j.ijpharm.2024.125040DOI Listing

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