AI Article Synopsis
- The study investigates the role of cerebrospinal fluid (CSF) flow cytometry in detecting central nervous system (CNS) infiltration and relapse in children with acute lymphoblastic leukemia (ALL).
- A total of 1301 patients were analyzed, revealing that those with positive CSF flow cytometry results had significantly higher rates of CNS relapse compared to those with negative results.
- The findings suggest that CSF flow cytometry can aid in risk stratification and treatment modifications, potentially leading to a reduction in CNS relapse rates among pediatric ALL patients.
Article Abstract
Objective: The central nervous system (CNS) is a frequent site of relapse in childhood acute lymphoblastic leukemia (ALL). This study aims to investigate the utility of cerebrospinal fluid (CSF) flow cytometry in detecting CNS infiltration and relapse.
Methods: Flow cytometry was used to detect CSF leukemia cells, and patients were categorized into the CSF Flow+ and CSF Flow- groups. The primary outcome was the cumulative incidence of relapse (CIR) in the CSF Flow+ and CSF Flow- groups.
Results: A total of 1301 patients were enrolled, 159 patients (12.2%) showed positive CSF flow cytometry results. The CNS Flow+ patients exhibited significantly higher rates of any CNS relapse (22.5% vs. 0.2%, p < 0.01) and isolated CNS relapse (10.7% vs. 0%, p < 0.01) compared to CNS Flow- patients. Cox regression analysis revealed that risk factors for isolated CNS relapse included a positive result of D46 minimal residual disease (MRD) and CSF Flow+ at a non-initial diagnosis. For any CNS relapse, the significant risk factors were CSF Flow+ at the initial diagnosis and CSF Flow+ at a non-initial diagnosis.
Conclusions: CSF flow cytometry may have clinical utility in detecting CNS infiltration among pediatric ALL patients. It could contribute to more effective risk stratification and treatment adjustments and potentially reduce the risk of CNS relapse.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626476 | PMC |
| http://dx.doi.org/10.1002/cam4.70452 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Missing the mark(ers): circulating endothelial cells and endothelial-derived extracellular vesicles are elevated in sickle cell disease plasma.
Front Immunol
December 2024
Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, United States.
Sickle cell disease (SCD) is a devastating hemolytic disease, marked by recurring bouts of painful vaso-occlusion, leading to tissue damage from ischemia/reperfusion pathophysiology. Central to this process are oxidative stress, endothelial cell activation, inflammation, and vascular dysfunction. The endothelium exhibits a pro-inflammatory, pro-coagulant, and enhanced permeability phenotype.
View Article and Find Full Text PDFImmune complexes-mediated activation of neutrophils in systemic lupus erythematosus is dependent on RNA recognition by toll-like receptor 8.
Front Immunol
December 2024
Division of Rheumatology, University of Washington, Seattle, WA, United States.
Introduction: Neutrophil activation is important in systemic lupus erythematosus (SLE). We previously demonstrated that ribonucleoprotein (RNP) immune complexes (ICs) promoted neutrophil activation in a TLR7/8-dependent manner. However, it remains unclear if this mechanism occurs in patients.
View Article and Find Full Text PDFA specific and adaptable approach to track CD206 macrophages by molecular MRI and fluorescence imaging.
Theranostics
January 2025
Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, 02129, MA.
The mannose receptor (CD206, expressed by the gene ) is a surface marker overexpressed by anti-inflammatory and pro-tumoral macrophages. As such, CD206 macrophages play key roles in the immune response to different pathophysiological conditions and represent a promising diagnostic and therapeutic target. However, methods to specifically target these cells remain challenging.
View Article and Find Full Text PDFThe influence of probiotic administration on selected leukocyte subpopulations and the serum amyloid A concentration in the peripheral blood of dairy cows during different lactation periods.
J Vet Res
December 2024
Student of the Faculty of Veterinary Medicine, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-612 Lublin, Poland.
Introduction: The aim of the study was to compare selected leukocyte subpopulations and the serum amyloid A (SAA) concentration in the peripheral blood of cows at different stages of lactation. The blood of cows receiving a probiotic as a dietary supplement was compared with the blood of cows not receiving it.
Material And Methods: The research was conducted on 20 pregnant dairy cows randomly divided into two groups of 10 cows each.
Determining the role of basophil activation testing in reported type 1 allergy to beta-lactam antibiotics.
Front Allergy
December 2024
Department of Dermatology, Eberhard Karls University, Tuebingen, Germany.
Background: Allergy to beta-lactam antibiotics (BLA), especially to penicillin, is the most commonly reported drug allergy by patients. Alternative antibiotics can yield negative consequences, such as extended hospitalization days due to less efficacy and overall higher costs. The basophil activation test (BAT) is an assay, in which activation of an individual's own basophils is quantified by flow cytometry.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!