Herein, we present a hitherto unexplored efficient strategy for rapidly constructing structurally constrained and intriguing polycyclic frameworks with two adjacent quaternary centers. Remarkably, this becomes possible through palladium-catalyzed six-fold domino crossover annulations of simple 1,2-bis(2-bromoaryl)ethynes and 1,2-diarylethynes. Notably, this approach demonstrates the synthesis of both C-symmetric and unsymmetric polycyclic products.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d4cc05380j | DOI Listing |
Publication Analysis
Top Keywords
palladium-catalyzed six-fold
8
six-fold domino
8
polycyclic frameworks
8
rapid pathway
4
pathway molecular
4
molecular complexity
4
complexity palladium-catalyzed
4
domino process
4
process access
4
access polycyclic
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!