Stress urinary incontinence (SUI) is a common disorder in females, which significantly affects the quality of life in females. There are many consensus that describe the safety of childbearing after surgery for SUI, but still, a large proportion of surgeons worldwide recommend that women should wait to complete childbearing before pursuing surgical treatment for SUI. There is also some opinion that if patients conceive after surgical treatment for SUI, women should be delivered by cesarean section. Trans obturator tape (TOT) procedure is the most commonly performed mid-urethral sling (MUS) surgery for the treatment of SUI. We are reporting a case where a P2+0 woman underwent a TOT procedure where we used a cheaper alternative to a conventional TOT kit. She conceived and underwent spontaneous vaginal delivery after the procedure. She remained continent in the follow-up even after one year of vaginal delivery.
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http://dx.doi.org/10.7759/cureus.73109 | DOI Listing |
Metabolism
December 2024
College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, South Korea. Electronic address:
Background & Aims: Metabolic dysfunction-associated steatotic liver (MASLD) progression is driven by chronic inflammation and fibrosis, largely influenced by Kupffer cell (KC) dynamics, particularly replenishment of pro-inflammatory monocyte-derived KCs (MoKCs) due to increased death of embryo-derived KCs. Adenosine A3 receptor (A3AR) plays a key role in regulating metabolism and immune responses, making it a promising therapeutic target. This study aimed to investigate the impact of selective A3AR antagonism for regulation of replenished MoKCs, thereby improving MASLD.
View Article and Find Full Text PDFNeurochem Int
December 2024
Department of Anesthesiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, China; Heilongjiang Province Key Laboratory of Research on Anesthesiology and Critical Care Medicine, Harbin, 150001, China. Electronic address:
Cerebral ischemia-reperfusion injury (CIRI) is a common and serious complication of reperfusion therapy in patients with ischemic stroke (IS). The regulation of microglia-mediated neuroinflammation to control CIRI has garnered considerable attention. The balance of iron metabolism is key to maintaining the physiological functions of microglia.
View Article and Find Full Text PDFCancer Lett
December 2024
Department of Thoracic Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China; Key Laboratory of Precision Diagnosis and Treatment of Lung Tumors in Shandong Provincial Medicine and Health, Shandong University, Jinan, China; Key Laboratory of Basic Research and Clinical Transformation of Thoracic Tumors in Shandong Provincial Colleges and Universities, Shandong University, Jinan, China. Electronic address:
Disulfiram (DSF), primarily applied in the therapy for alcohol addiction, has been demonstrated to possess the promising capability of anti-tumor in many human cancers, including esophageal squamous cell carcinoma (ESCC). To date, almost all studies about DSF in ESCC are focusing on investigating either drug combinations or nanoparticle-based delivery systems. However, the exact molecular mechanisms mediating the response to DSF in ESCC are totally unknown.
View Article and Find Full Text PDFAppl Environ Microbiol
December 2024
Ocean College, Zhejiang University, Zhoushan, China.
This study explored the genomic alterations in , a key yeast in industrial biotechnology, under both spontaneous and mutagen-induced conditions. Our findings reveal that spontaneous mutations occur at a rate of approximately 4 × 10 events per base pair per cell division, primarily manifesting as single-nucleotide variations (SNVs) and small insertions and deletions (InDels). Notably, C-to-T/G-to-A transitions and C-to-A/G-to-T transversions dominate the spontaneous SNVs, while 1 bp deletions, likely resulting from template slippage, are the most frequent InDels.
View Article and Find Full Text PDFJ Respir Biol Transl Med
December 2024
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Respiratory diseases pose a major public health challenge globally, necessitating collaborative efforts between basic researchers and clinicians for effective solutions. China, which is heavily impacted by a broad spectrum of respiratory disorders, has made notable strides in both research and clinical management of these diseases. The International Respiratory Medicine (IRM) meeting was organized with the primary goal of facilitating the exchange of recent research developments and promoting collaboration between Chinese and American scientists in both basic and clinical research fields.
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