The anterior cruciate ligament (ACL) is integral to the stability of the knee joint, serving to limit anterior tibial translation and regulate rotational movements. ACL injuries are among the most common and debilitating forms of knee trauma, often resulting in joint effusion, muscular atrophy, and diminished athletic capabilities. Despite the established efficacy of ACL reconstruction as the standard treatment, it is not uniformly successful. Consequently, there is a growing interest in novel biotherapeutic interventions as potential alternatives. This comprehensive review examines the latest advancements in ACL biotherapy, encompassing the application of hyaluronic acid, self-assembled short peptides, growth factors, stem cell therapy, gene therapy, platelet-rich plasma therapy, bone marrow aspirate concentrate cells, extracorporeal shock wave, electrical stimulation and cross bracing protocol. The collective aim of these innovative treatments is to facilitate the restoration of the ACL's native biological and biomechanical integrity, with the ultimate goal of enhancing clinical outcomes and the functional recovery of affected individuals.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620901 | PMC |
| http://dx.doi.org/10.3389/fbioe.2024.1455225 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hallmarks of Appetite: A Comprehensive Review of Hunger, Appetite, Satiation, and Satiety.
Curr Obes Rep
January 2025
CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy.
Purpose Of Review: The present review describes the available literature on the physiologic mechanisms that modulate hunger, appetite, satiation, and satiety with a particular focus on well-established and emerging factors involved in the classic satiety cascade model.
Recent Finding: Obesity is a significant risk factor for numerous chronic conditions like cancer, cardiovascular diseases, and diabetes. As excess energy intake is considered by some to be the primary driver of weight gain, tremendous collective effort should be directed toward reducing excessive feeding at the individual and population levels.
Performance of Radiomics-based machine learning and deep learning-based methods in the prediction of tumor grade in meningioma: a systematic review and meta-analysis.
Neurosurg Rev
January 2025
Department of Neurosurgery, Mount Sinai Hospital, Icahn School of Medicine, New York City, NY, USA.
Currently, the World Health Organization (WHO) grade of meningiomas is determined based on the biopsy results. Therefore, accurate non-invasive preoperative grading could significantly improve treatment planning and patient outcomes. Considering recent advances in machine learning (ML) and deep learning (DL), this meta-analysis aimed to evaluate the performance of these models in predicting the WHO meningioma grade using imaging data.
View Article and Find Full Text PDFRecent advances in engineering non-native microorganisms for poly(3-hydroxybutyrate) production.
World J Microbiol Biotechnol
January 2025
Biofuels Institute, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, 212013, China.
Poly(3-hydroxybutyrate) (PHB) is a biodegradable polymer that belongs to a group of polymers called polyhydroxyalkanoates (PHAs). PHB can be synthesized from renewable resources, making it a promising alternative to petroleum-derived plastics. It is also considered non-toxic, biodegradable, and biocompatible, which makes it suitable for various applications in the medicine and biomedicine.
View Article and Find Full Text PDFUnlocking the Power of 3D Convolutional Neural Networks for COVID-19 Detection: A Comprehensive Review.
J Imaging Inform Med
January 2025
College of Science and Engineering, Hamad Bin Khalifa University, Ar-Rayyan, Qatar.
The advent of three-dimensional convolutional neural networks (3D CNNs) has revolutionized the detection and analysis of COVID-19 cases. As imaging technologies have advanced, 3D CNNs have emerged as a powerful tool for segmenting and classifying COVID-19 in medical images. These networks have demonstrated both high accuracy and rapid detection capabilities, making them crucial for effective COVID-19 diagnostics.
View Article and Find Full Text PDFClinical spectrum of positional downbeat nystagmus: a diagnostic approach.
J Neurol
January 2025
Department of Neurology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL, 60637, USA.
Positional downbeat nystagmus (pDBN) is a common finding in dizzy patients, with etiologies ranging from benign paroxysmal positional vertigo (BPPV) to central vestibular lesions. Although peripheral pDBN often presents with distinct clinical features that differentiate it from BPPV, diagnosing its etiology can be challenging. A thorough clinical evaluation, including the physical characteristics of the nystagmus, response to positional maneuvers, and neurological findings, is often sufficient to diagnose conditions that provoke pDBN such as anterior canal BPPV, atypical posterior canal BPPV, and central causes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!