Breast milk, a fundamental component of infant nutrition, may serve as a reservoir for various metal(loid)s, which could pose significant health risks to infants of mothers exposed to toxic metals. Human exposure levels to metal(loid)s vary across regions, influenced by differences in diet, lifestyle, and environmental factors. This systematic review compares metal(loid) concentrations in breast milk from Sub-Saharan Africa (SSA) and Mediterranean Europe (Med. Europe), identifying key determinants of exposure. PubMed, Scopus, and Google Scholar were searched for articles reporting metal concentrations in human breast milk samples from SSA and Med. Europe. Weighted mean concentrations were estimated and compared between the two regions. Twenty-five studies from SSA and seventeen from Med. Europe were included in the review. Mean concentrations of cadmium (12.38 ± 1.21 µg/L vs 0.22 ± 0.51 µg/L; p < 0.0001), lead (14.96 ± 8.10 µg/L vs 1.16 ± 4.00 µg/L; p < 0.0001), and mercury (2.01 ± 1.37 µg/L vs 0.95 ± 4.32 µg/L; p = 0.008) were higher in breast milk samples from SSA than Med. Europe. Conversely, breast milk samples from SSA had lower concentrations of selenium (7.38 ± 2.67 µg/L vs 13.09 ± 16.89 µg/L; p < 0.0001) and iron (138.78 ± 106.33 µg/L vs 371.97 ± 446.74 µg/L; p < 0.0001) than those from Med. Europe. Key determinants of metal(loid)s levels in breast milk included maternal smoking, dietary patterns, and environmental exposure. There is an urgent need for effective interventions and policies to reduce metals exposure, particularly in SSA, to safeguard maternal and infant health.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621596 | PMC |
http://dx.doi.org/10.1016/j.crtox.2024.100201 | DOI Listing |
Talanta
December 2024
College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang, 471934, China.
An europium metal organic framework (Eu-DBPA-Phen) was synthesized using 2,5-dibromoterephthalic acid (HDBPA) and 1-10-phenanthroline (Phen) as ligands. A straightforwardc quasi-ratiometric fluorescence probe was then developed for the detection of levofloxacin (LVF) by the simplistic combination of red-emitting Eu-DBPA-Phen and the inherent blue auto-fluorescence of the target. The probe exhibits the advantages of wide linear range (0.
View Article and Find Full Text PDFMol Cell Endocrinol
December 2024
Department of Pediatric Laboratory, Affiliated Children's Hospital of Jiangnan University, Wuxi, 214023, China. Electronic address:
The regulatory effect of breastfeeding on offspring metabolism has garnered significant attention as an effective strategy in combating childhood obesity. However, the underlying mechanism remains largely unknown. Through integrated analysis of multiple human milk peptide databases and functional screening, MDPAO1 (milk-derived peptide associated with obesity 1) was identified as having potential activity in promoting the expression of thermogenic genes.
View Article and Find Full Text PDFBackground: Infants exposed to HIV but uninfected have altered immune profiles which include heightened systemic inflammation. The mechanism(s) underlying this phenomenon is unknown. Here, we investigated differences in neonatal gut bacterial and viral microbiome and associations with inflammatory biomarkers in plasma.
View Article and Find Full Text PDFEur J Clin Nutr
December 2024
Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, 430030, Wuhan, China.
Background: Breastfeeding and human milk are the normative standards for infant feeding and nutrition.
Objectives: We aimed to examine the association of breastfeeding practices during the first year of life with subsequent infant respiratory tract infections (RTIs).
Methods: The study was a secondary analysis embedded in the Tongji Maternal and Child Health Cohort study.
Medicine (Baltimore)
December 2024
Newborn Screening Center, Jinan Maternal and Child Care Hospital, Jinan, P.R.China.
Rationale: The high clinical heterogeneity of hypermethioninemia caused by MAT1A gene defects has resulted in a paucity of studies examining the association between clinical phenotypes, biochemical characteristics, and gene mutations in this patient group. Furthermore, the indications for therapeutic interventions in patients remain unclear. The objective of this study is to provide a foundation for clinical diagnosis, genetic counseling, and follow-up management of hypermethioninemia caused by MAT1A gene defects.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!