AI Article Synopsis
- Natural enzyme-based therapies for cancer often struggle with stability during delivery, limiting their effectiveness.
- Researchers created a new nanoplatform called GCI@RPCM that uses natural enzymes and a photothermal agent, enclosed in special materials targeting tumors and responding to heat.
- This system can release enzymes when activated by NIR light, significantly reducing tumor cells and completely eradicating tumors in tests without causing harm to the rest of the body.
Article Abstract
Natural enzyme-based catalytic cascades have garnered increasing attention in cancer therapy, but their clinical utility is greatly limited due to loss of function during delivery. Here, we developed an enzyme delivering nanoplatform (GCI@RPCM) with great stability and achieve NIR-triggered enzyme dynamic therapy. This nanoplatform is created with encapsulation of nature enzymes (glucose oxidase and chloroperoxidase) and photothermal agent (indocyanine green) within tumor targeting and thermo-responsive phase change materials (RPCMs). With NIR irradiation for 10 min, GCI@RPCM can release 41 % of the enzymes and generate abundant reactive oxygen species (ROS), which showed significant tumor cell inhibition. After intravenous injection, GCI@RPCM can efficiently accumulate at the tumor site and local NIR treatment resulted in complete tumor eradication without detectable systemic toxicity. This study provides a highly stable and NIR-controllable smart delivery system and achieve enzyme dynamic therapy for enhanced breast cancer therapy.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625163 | PMC |
| http://dx.doi.org/10.1016/j.mtbio.2024.101345 | DOI Listing |
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