"Bupe by the Book": A study protocol for a pilot randomized controlled trial of library-facilitated telehealth to increase buprenorphine treatment among unstably housed individuals.

Background: Accessing opioid use disorder (OUD) treatment is difficult for individuals in unstable housing. This population often uses public libraries for computer and internet access, which could provide telehealth access to OUD treatment. Therefore, we developed a novel 12-week library-facilitated telehealth intervention study called "Bupe by the Book" (BBB), which uses library resources to facilitate the initiation and retention of OUD treatment with buprenorphine.

Methods: This study involved a partnership between the San Diego Public Library and a federally qualified healthcare center attached to a homeless shelter (Father Joe's Villages (FJV) Village Health Center). We codesigned a pilot randomized controlled trial to evaluate a library-facilitated telehealth intervention in San Diego, California. We evaluated the intervention for its feasibility and acceptability and to obtain an estimate of the effect of the intervention on buprenorphine treatment outcomes. Individuals reporting homelessness and OUD (with or without other substance use) were eligible. Forty library patrons were recruited via flyers, screened for eligibility, and referred to the FJV Health Center for initial buprenorphine treatment intake visits. Participants who completed intake were enrolled and randomized to the library-facilitated telehealth condition, which involved the use of library internet and computer resources for follow-up visits to the clinic for buprenorphine treatment. The participants completed treatment follow-up in person or by phone in the control condition. Planned analyses (not powered to assess efficacy) will provide effect size estimates of the library-facilitated telehealth intervention on 1) buprenorphine use (measured in weekly urine drug screenings), 2) use of illicitly manufactured fentanyl (IMF) and other opioids (measured in weekly urine drug screens), 3) number of buprenorphine prescription pick-ups, 4) number and frequency of clinic visits, and 5) self-reported substance use, mental health, and quality of life measures at 1, 2, 4, 8, and 12 weeks.

Discussion: The findings from this pilot study may support the adoption of library-facilitated telehealth treatment as a feasible and acceptable strategy to engage and retain unstably housed people with OUD in buprenorphine treatment. The lessons from this pilot study include the importance of community-academic partnerships in sustainably adapting interventions in community-based settings.

Trial Registration: This trial was registered prospectively at ClinicalTrials.gov (registration number NCT05872386) on May 24, 2023.