Severity: Warning
Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 143
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3098
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: Attempt to read property "Count" on bool
Filename: helpers/my_audit_helper.php
Line Number: 3100
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3100
Function: _error_handler
File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Alzheimer's disease and related dementia are associated with significant societal costs and economic burdens and have been associated with decreases in cortical gray matter volume. This pilot cross-sectional study investigates the relationship between total fiber concentration in diet, total calorie density per diet, and regional GMV in a cohort of 190 patients aged 20 to 79 years, utilizing data from the 2015 National Health Interview Survey Supplement and T1-weighted magnetic resonance imaging (MRI) collected at the McCausland Center for Brain Imaging. Gray matter volumes were quantified using the CAT12 voxel-based morphometry toolbox and statistical correlations between GMV and dietary measures were assessed using Spearman's rank order correlation coefficient. Our exploratory analysis revealed a significant positive correlation between dietary fiber consumption and GMV in 16 different areas, including the right Hippocampus (r (190) = 0.196, p = 0.003) and left Hippocampus (r (190) = 0.135, p = 0.032), when controlling for age and race of participants. Our analyses revealed significantly negative correlations between total calorie density per diet and localized GMV in 3 different brain areas, including the right Precentral Gyrus (r (190) = -0.15, p = 0.039) and right Thalamic Pulvinar (r (190) = -0.155, p = 0.033), when controlling for participant race. Together, our initial findings suggest that dietary fiber and calorie density are associated with GMV even after controlling for relevant demographic variables. If replicated, these findings could have important implications for dietary advice given to individuals at risk for developing MCI or more serious forms of dementia.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623756 | PMC |
http://dx.doi.org/10.21203/rs.3.rs-5338934/v1 | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!