AI Article Synopsis
- Neurogenesis is being explored as a treatment for brain disorders, with a focus on how astrocytic (star-shaped brain cells) mitochondria contribute to this process.
- Astrocytic mitochondrial functions are linked to neurogenesis through their roles in providing metabolic support, maintaining calcium balance, and releasing neurotrophic factors, but the underlying mechanisms need more research.
- Understanding mitochondrial issues in astrocytes is crucial for developing therapies for conditions like Alzheimer's and depression, suggesting targeting these mitochondria might boost brain cell repair.
Article Abstract
Neurogenesis has emerged as a promising therapeutic approach for central nervous system disorders. The role of neuronal mitochondria in neurogenesis is well-studied, however, recent evidence underscores the critical role of astrocytic mitochondrial function in regulating neurogenesis and the underlying mechanisms remain incompletely understood. This review highlights the regulatory effects of astrocyte mitochondria on neurogenesis, focusing on metabolic support, calcium homeostasis, and the secretion of neurotrophic factors. The effect of astrocytic mitochondrial dysfunction in the pathophysiology and treatment strategies of Alzheimer's disease and depression is discussed. Greater attention is needed to investigate the mitochondrial autophagy, dynamics, biogenesis, and energy metabolism in neurogenesis. Targeting astrocyte mitochondria presents a potential therapeutic strategy for enhancing neural regeneration.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621070 | PMC |
| http://dx.doi.org/10.3389/fnmol.2024.1516119 | DOI Listing |
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