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| http://dx.doi.org/10.4274/jtgga.galenos.2024.2024-10-3 | DOI Listing |
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Lipid imbalance and inflammatory oxylipin cascade at the maternal-fetal interface in recurrent spontaneous abortion.
Heliyon
December 2024
Department of Obstetrics and Gynaecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Article Synopsis
- RSA is linked to metabolic imbalances at the maternal-fetal interface, especially concerning essential fatty acids and oxylipins, which may contribute to the risk of spontaneous abortion.
- Research involved analyzing samples from women experiencing spontaneous abortion and those with normal pregnancies, measuring fatty acid levels and enzyme expressions using advanced techniques like GC-MS and LC-MS.
- Findings showed that women with recurrent spontaneous abortion had higher omega-6 fatty acid levels in their plasma and chorionic villi but lower levels in the decidua, suggesting a possible dysregulation of fatty acid transport affecting pregnancy outcomes.
Second trimester medical abortion in acute promyelocytic leukaemia.
BMJ Case Rep
December 2024
Haematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Acute promyelocytic leukaemia (APL) is a highly lethal haematological malignancy. It is rare in pregnancy and may be fatal if not managed promptly and appropriately. A woman in her 20s presented with high-grade fever at 16 weeks of her third pregnancy.
View Article and Find Full Text PDFRelationship between relaxin-2 levels in serum and mode of conception in twin gestations: A prospective cohort study.
J Obstet Gynaecol Res
January 2025
Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy.
Aim: Relaxin is a peptide hormone commonly associated with pregnancy when it is thought to play a role in modulating various physiological processes to optimize maternal-fetal adaptation. In twin pregnancies these adaptive requirements are higher than in singleton pregnancies, therefore it is important to understand how circulating relaxin behaves in such conditions. This prospective cohort study aims to determine the serum relaxin-2 levels throughout gestation in twin pregnancies and to investigate its association with the mode of conception.
View Article and Find Full Text PDFMaternal cytokine profiles in second and early third trimester are not predictive of preterm birth.
PLoS One
December 2024
Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Alberta, Canada.
Previous studies have investigated whether inflammatory cytokines in maternal circulation are associated with preterm birth. However, many have reported inconsistent results, and few have investigated cytokine trends through gestation, particularly with respect to subtypes of preterm birth. We explored levels of 15 inflammatory cytokines and growth factors in plasma and serum collected in the second (17-23 weeks, timepoint 1 (T1)) and third (28-32 weeks, timepoint 2 (T2)) trimesters with respect to subtypes of preterm birth: spontaneous preterm labour (sPTL), preterm premature rupture of membranes (PPROM), and medically indicated preterm birth (mPTB).
View Article and Find Full Text PDFPersonal growth during early and advanced pregnancy according to women's mode of conception.
J Reprod Infant Psychol
December 2024
School of Social Work, Bar-Ilan University, Ramat-Gan, Israel.
Background: Pregnancy can be a complex and stressful period, especially for women conceiving through fertility treatment, but this can foster the experience of personal growth (PG). Most of the knowledge on women's PG during pregnancy is based on a single measurement and relates to conceiving achieved through fertility treatments in general. Relying on Schaefer and Moos's PG model, the current prospective study sought to (1) investigate the differences in PG according to women's mode of conception (spontaneous; first-line fertility treatment; IVF) and (2) examine the contribution of the mode of conception, perceived stress, self-mastery, and cognitive appraisal (threat, challenge, and self-efficacy) to PG in two phases during pregnancy.
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