Chitosan and gelatin based sprayable hydrogels incorporating photothermal and long-acting antibiotic sterilization for infected wound management with shape adaptability. | LitMetric
Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, Xinjiang, China. Electronic address:
Published: February 2025
AI Article Synopsis
Article Abstract
Severe skin damage resulting from acute trauma is often accompanied by uncontrolled bleeding, microbial infections, and delayed wound healing. Herein, multifunctional sprayable hydrogels (CT-CS-ZIF@CIP Gel) were developed for wound management by incorporating antibacterial nanoplatforms (CT-CS-ZIF@CIP) into photocurable gels consisting of chitosan methacrylate and gallic acid grafted gelatin. The nanoplatform was initially constructed by sequentially loading CuSe (CS) and ciprofloxacin-decorated zeolitic imidazolate framework-8 (ZIF@CIP) onto Cu-doped Ti MOF (CT), in which CS served as a photothermal agent, ZIF enabled pH-responsive release of CIP, and CT acted as carriers for CS and ZIF@CIP. The hydrogel precursor can be sprayed onto wound surface and photocured quickly, allowing hydrogel to fit the wound shape and form a protective barrier onsite. The resultant hydrogel exhibited excellent hemostatic ability, adhesion properties, cytocompatibility and toxin adsorption capacity. By integrating CS for short-term photothermal therapy with CIP for long-acting chemotherapy, the CT-CS-ZIF@CIP Gel demonstrated 100 % sterilization of three bacterial strains. Furthermore, moderate release of zinc and copper ions promoted wound healing. The therapeutic efficacy of hydrogel was validated in an infected cutaneous mouse model. Overall, this work presents a versatile sprayable hydrogel that can be flexibly applied to irregular dynamic wounds for safe and effective wound management.
Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China; Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou 510515, China; School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China. Electronic address:
Lead (Pb) exposure is widely acknowledged as a risk factor for cardiovascular diseases. Previous studies have established neutrophil involvement in Pb-induced cardiovascular injuries; however, the underlying mechanisms remain unclear. To address this knowledge gap, the binding targets of Pb in neutrophils and their roles in regulating neutrophil extracellular trap (NET) formation were investigated.
St Andrew's Anglia Ruskin (StAAR) Research Group, St Andrew's Centre for Plastic Surgery & Burns, Broomfield Hospital, Court Road, Chelmsford CM1 7ET, UK. Electronic address:
Background: Infected animal bites and localised infections are traditionally managed by inpatient admission, intravenous antibiotics, and localised washout +/- debridement. Our hand trauma protocol was modified to accommodate the challenges faced in delivering this pathway during the COVID-19 pandemic.
Objective: To evaluate the outcomes of two management pathways, ambulatory (2020) vs inpatient (2019), at a single tertiary referral centre.
Introduction: Burn wound management is challenging, especially in paediatric patients when optimising outcomes. Superficial burns are generally managed conservatively with dressings; however, frequent dressing changes can be a source of pain and discomfort. Cellulose dressings mitigate these problems, and current reports in the literature have demonstrated positive outcomes when compared against routine dressing types.
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, P. R. China.
Burn injuries often cause prolonged oxidative stress and inflammatory pain due to an initial increase in inflammatory responses, consequently exacerbating depressive disorders and severely impairing patients' quality of life. The primary function of traditional burn dressings is to prevent infection and facilitate tissue repair. However, these dressings are not intended for the inflammatory pain and depression that often occur during recovery.
Introduction: Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by rapidly enlarging, painful ulcers with undermined borders. The management of PG is challenging due to the lack of standardized evidence-based treatments.
Areas Covered: This review examines recent efforts to establish standardized outcomes for clinical trials to facilitate the drug development process for PG.
