AI Article Synopsis
- Substance use disorders cause changes in the brain's neuroendocrine and neuromodulator systems, impacting reward and stress responses.
- Chronic substance use can lead to new health issues and worsen existing ones, creating a cycle of disease.
- Understanding the biochemical pathways involved in these comorbidities may help in developing new medications or repurposing existing ones for better treatment of drug dependence.
Article Abstract
Substance use disorders are associated with structural and functional changes in the neuroendocrine, neuromediator, and neuromodulator systems in brain areas involved in the reward and stress response circuits. Chronic intoxication provokes emergence of somatic diseases and aggravates existing pathologies. Substance use disorders and somatic diseases often exacerbate the clinical courses of each other. Elucidation of biochemical pathways common for comorbidities may serve as a basis for the development of new effective pharmacotherapy agents, as well as drug repurposing. Here, we discussed molecular mechanisms underlying integration of visceral systems into the central mechanisms of drug dependence.
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| http://dx.doi.org/10.1134/S0006297924110026 | DOI Listing |
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