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Talking about trauma: A systematic review of young people's reactions to trauma-focused research.
Clin Psychol Rev
January 2025
Clinical and Health Psychology, School of Health in Social Science, University of Edinburgh, UK; Department of Psychological Services and Research, NHS Dumfries & Galloway, UK.
Concerns persist about the potential negative impact of asking young people about their trauma experiences in a research context. Previous research on this ethical issue has focused on adult populations, and the limited evidence for young people has limitations. This systematic review synthesised empirical evidence of young people's reactions to trauma-focused research, and associated participant and study characteristics.
View Article and Find Full Text PDFWe cannot repeat history again: a call to action to centre indigenous leadership as we prepare for the next pandemic.
Int J Equity Health
January 2025
Department of Public Health, Auckland University of Technology, Auckland, New Zealand.
Indigenous communities worldwide continue to disproportionately bear the burden during pandemics due to ongoing health inequities and systemic exclusion from pandemic decision-making processes. As the global community prepares for the next pandemic, it is critical to prioritise Indigenous leadership and governance within public health responses. This commentary highlights successful models of Indigenous-led pandemic responses during COVID-19 in Canada and Australia.
View Article and Find Full Text PDFDifferences in the distribution of steroids in sterol-containing liposomes: A study by liposome electrokinetic chromatography.
J Chromatogr A
January 2025
Department of Chemistry, Faculty of Science, POB 55 (A.I. Virtasen aukio 1), 00014 University of Helsinki, Helsinki, Finland. Electronic address:
This study was conducted to investigate possible differences in the interactions of some selected steroids based on their distribution coefficients with cholesterol- or ergosterol-rich liposomes. Structurally cholesterol and ergosterol have very close resemblance to each other and generally it is thought that they behave in a similar manner. In this work we will show that this is not the case.
View Article and Find Full Text PDFvariants cause a range of epilepsy syndromes, including Dravet syndrome, leading to early cognitive and functional impairment. Despite advances in medical management, drug-resistant epilepsy remains common. Vagal nerve stimulation (VNS) has been suggested reducing seizure frequency in these patients but there is a lack of long-term follow-up, quantitative analysis that corrected for confounding factors such as antiseizure medications (ASMs) and the impact of VNS settings on response.
View Article and Find Full Text PDFFacioscapulohumeral muscular dystrophy (FSHD) is a potentially devastating muscle disease caused by de-repression of the toxic gene in skeletal muscle. FSHD patients may benefit from inhibition therapies, and although several experimental strategies to reduce levels in skeletal muscle are being developed, no approved disease modifying therapies currently exist. We developed a CRISPR-Cas13b system that cleaves mRNA and reduces DUX4 protein level, protects cells from DUX4-mediated death, and reduces FSHD-associated biomarkers .
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