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Letter to the editor for the article "Does coiling of the proximal end of the ureteral stent affect stent-related symptoms?".
World J Urol
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Department of Urology, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, China.
How does dopamine convert into norepinephrine? Insights on the key step of the reaction.
J Mol Model
January 2025
Laboratorio de Química Teórica Computacional (QTC), Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Avenida Vicuña Mackenna 4860, 7820436, Santiago de Chile, Chile.
Context: Dopamine -monooxygenase (D M) is an essential enzyme in the organism that regioselectively converts dopamine into R-norepinephrine, the key step of the reaction, studied in this paper, is a hydrogen atom transfer (HAT) from dopamine to a superoxo complex on D M, forming a hydroperoxo intermediate and dopamine radical. It was found that the formation of a hydrogen bond between dopamine and the D M catalyst strengthens the substrate-enzyme interaction and facilitates the HAT which takes place selectively to give the desired enantiomeric form of the product. Six reactions leading to the hydroperoxo intermediate were analyzed in detail using theoretical and computational tools in order to identify the most probable reaction mechanism.
View Article and Find Full Text PDFReply to the letter to the editor "Advancements in cardiovascular risk assessment: the prognostic value of arterial stiffness metrics".
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Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, Texas, USA.
Writing an effective and succinct cover letter: A practical guide.
Tunis Med
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Université de Sousse, Faculté de Médecine de Sousse, Hôpital Farhat Hached, Laboratoire de recherche LR12SP09 « Insuffisance cardiaque », 4000 Sousse, Tunisie.
Introduction: The cover letter is a critical component of medical journal submissions, often influencing acceptance decisions. However, authors frequently underestimate its importance. This narrative review aimed to provide guidance for authors on writing effective and succinct cover letters.
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