Agency is action aimed at goals selected by an agent. A deterministic world view leaves scant room for agency. To reconcile the arguments, we represent action as nested control systems, ranging from clearly deterministic to clearly volitional. Negative feedback minimizes deviations from setpoints (goals). Goals are determined by higher modules in a hierarchy of systems, ranging from gamma-efferent spindles through reflexes to operant responses; these last, and the larger system that contains them, called the Self, comprise volitional agents. When operants become habitual they descend to closed teleonomic systems-automaticity. Change in emotional states, and unpredicted changes in the context-raise them back to full volitional systems. At the highest level is the Self-the brain's model of the agent. When aroused out of open teleonomic functioning, it must reconsider means and ends. It does so by simulating action plans, using the same neural systems it uses to effect them. The simulated stimuli and responses are conscious, approximating their perceptions as experienced in real time; this verisimilitude gives them their hedonic value. Positive feedback plays a key role in these complex adaptive systems, as it focuses and holds attention on the most salient percepts and goals, permitting the self-organization of action plans. The Self is not a separate entity, but a colloquy of command modules wearing the avatar of the agent. This system is put into correspondence with Grossberg's Adaptive Resonance Theory. Free will and determinism emerge not as binary opposites, but the modulating inputs to a spectrum of systems.
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http://dx.doi.org/10.1080/00221309.2024.2433277 | DOI Listing |
JMIR Form Res
January 2025
Department of Biomedical Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Background: The iAide2 (Tokai) physical activity monitoring system includes diverse measurements and wireless features useful to researchers. The iAide2's sleep measurement capabilities have not been compared to validated sleep measurement standards in any published work.
Objective: We aimed to assess the iAide2's sleep duration and total sleep time (TST) measurement performance and perform calibration if needed.
Foodborne Pathog Dis
January 2025
Departamento de Alimentos e Nutrição Experimental, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil.
Foodborne pathogens have always been of public health concern and represent safety issues for food processors. These pathogens develop new ways to overcome antibiotics, survive in different environmental conditions, and the ability to reproduce in many hostile environments configure them as serious health hazards. Considering the huge number of microorganisms, three bacterial representatives were selected to provide a better knowledge about the question of which one is the worst enemy for humans, from the food industry point of view, taking into consideration their multiplication specificity, virulence, and resistance.
View Article and Find Full Text PDFMol Plant Microbe Interact
January 2025
ETH Zurich Department of Environmental Systems Science, Plant Pathology Group, Institute of Integrative Biology, Zurich, Zürich, Switzerland.
Adaptation to new climates poses a significant challenge for plant pathogens during range expansion, highlighting the importance of understanding their response to climate to accurately forecast future disease outbreaks. The wheat pathogen is ubiquitous across most wheat production regions distributed across diverse climate zones. We explored the genetic architecture of thermal adaptation using a global collection of 411 strains that were phenotyped across a wide range of temperatures and then included in a genome-wide association study.
View Article and Find Full Text PDFJ Biochem
January 2025
Division of Cancer and Senescence Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
As the global population continues to age, understanding the complex role of cellular senescence and its implications in healthy lifespans has gained increasing prominence. Cellular senescence is defined as the irreversible cessation of cell proliferation, accompanied by the secretion of a range of pro-inflammatory factors, collectively termed the senescence-associated secretory phenotype (SASP), in response to various cellular stresses. While the accumulation of senescent cells has been strongly implicated in the aging process and the pathogenesis of age-related diseases owing to their pro-inflammatory properties, recent research has also highlighted their essential roles in processes such as tumour suppression, tissue development, and repair.
View Article and Find Full Text PDFPhys Eng Sci Med
January 2025
Physics Department, Instituto Zunino, Obispo Oro 423, X5000BFI, Córdoba, Argentina.
Treatment Planning Systems (TPS) offer algorithms for distortion correction (DC) of Magnetic Resonance (MR) images, whose performances demand proper evaluation. This work develops a procedure using a virtual phantom to quantitatively assess a TPS DC algorithm. Variations of the digital Brainweb MR study were created by introducing known distortions and Control Points (CPs).
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