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Effect of Creatine Monohydrate Supplementation on Macro- and Microvascular Endothelial Function in Older Adults: A Pilot Study.
Nutrients
December 2024
Department of Health, Nutrition, and Food Sciences, Florida State University, 120 Convocation Way, Tallahassee, FL 32306, USA.
A pilot study was conducted to investigate the effect of four weeks of creatine monohydrate (CrM) on vascular endothelial function in older adults. In a double-blind, randomized crossover trial, twelve sedentary, healthy older adults were allocated to either the CrM or placebo (PL) group for four weeks, at a dose of 4 × 5 g/day for 5 days, followed by 1 × 5 g/day for 23 days. Macrovascular function (flow-mediated dilation [FMD%], normalized FMD%, brachial-ankle pulse wave velocity [baPWV], pulse wave analysis [PWA]), microvascular function (microvascular reperfusion rate [% StO/sec]), and biomarkers of vascular function (tetrahydrobiopterin [BH], malondialdehyde [MDA], oxidized low-density lipoprotein [oxLDL], glucose, lipids) were assessed pre- and post-supplementation with a four-week washout period.
View Article and Find Full Text PDFProposal for Clinical Management of Nodules Diagnosed as Atypia of Undetermined Significance via Thyroid Fine-Needle Aspiration Cytology in the Absence of Molecular Testing.
Cytopathology
January 2025
Department of Internal Medicine, Kuma Hospital, Kobe, Japan.
Objective: Molecular testing is recommended for risk stratification of atypia of undetermined significance (AUS) nodules in the USA; however, it is not routinely performed in some countries owing to limited availability and affordability. Here, we propose a risk stratification algorithm for AUS nodules when molecular testing is unavailable.
Methods: We examined 304 (4.
Exploring the influence of parametrized pulsatility on left ventricular washout under LVAD support: a computational study using reduced-order models.
Comput Methods Biomech Biomed Engin
March 2024
RWTH Aachen University, Aachen, Germany.
Introducing pulsatility in LVADs is known to reduce complications such as stagnation and thrombosis, but it is an ongoing topic of research on what the optimal form is. We present a framework consisting of parametrized full-order simulations, reduced-order models, and sensitivity analysis to systematically quantify the effects of parametrized pulsatility on washout. As a sample problem, we study the washout in an idealized 2D left ventricle and a parametrized sinusoidal LVAD flow rate.
View Article and Find Full Text PDFIndividual Responses to Repeated Dosing with Anthocyanin-Rich New Zealand Blackcurrant Extract During High-Intensity Intermittent Treadmill Running in Active Males.
Nutrients
December 2024
Institute of Applied Sciences, University of Chichester, College Lane, Chichester PO19 6PE, UK.
Unlabelled: Intake of New Zealand blackcurrant (NZBC) extract for 7 days has been shown to improve high-intensity intermittent running (HIIR) performance.
Objectives: We examined the repeat response of NZBC extract on HIIR performance.
Methods: Sixteen active males (age: 23 ± 3 yrs, height: 179 ± 5 cm, mass: 79 ± 11 kg, V˙O: 55.
Achieving stable partial nitrification by exploiting lag phase of NOB recovery for selective washout.
Environ Res
January 2025
Key Laboratory of Water Science and Water Environment Recovery Engineering, Beijing University of Technology, Beijing, 100123, China; State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, China.
Stable inhibition of nitrite-oxidizing bacteria (NOB) is a significant challenge in achieving partial nitrification (PN) and partial nitrification-anaerobic ammonia oxidation (PNA). Growing evidence suggested that NOB can develop resistance to suppression over time, leading to the re-enrichment of NOB within reactors. To address these issues, this study aimed to achieve stable PN by regulating SRT to selectively washout NOB during the lag phase of activity recovery following FA/FNA exposure.
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