AI Article Synopsis
- Neurocognitive Disorders (NCDs) impact cognitive abilities like memory and problem-solving, typically arising from central nervous system issues.
- Research highlights that inflammation in the hippocampus, triggered by microglial cells, plays a key role in cognitive decline associated with NCDs.
- The receptor TREM1, which increases during inflammation, enhances microglial activation and may be vital in the inflammatory processes linked to NCDs.
Article Abstract
Neurocognitive Disorders (NCDs) primarily affect cognitive functions, including learning, memory, perception, and problem-solving. They predominantly arise as pathological sequelae of central nervous system (CNS) disorders. Emerging evidence suggests that microglial inflammatory activation within the hippocampus underlies the pathogenesis of cognitive impairment. Triggering receptor expressed on myeloid cells 1 (TREM1), a pattern-recognition receptor on microglia, becomes upregulated in response to injury and synergistically amplifies inflammatory responses mediated by other pattern-recognition receptors, leading to uncontrolled inflammation. While TREM1 is lowly expressed in the resting state, its upregulation upon exposure to injurious inflammatory stimuli promotes microglial activation and contributes to the development of NCDs. Consequently, TREM1 may serve as a critical receptor in microglia-mediated inflammation. This article reviews the current understanding of TREM1 and its role in NCDs pathogenesis.
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| http://dx.doi.org/10.1016/j.brainresbull.2024.111162 | DOI Listing |
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