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Deferral of routine percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation: rationale and design of the PRO-TAVI trial: the PRO-TAVI trial: rationale and design.
Am Heart J
December 2024
Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Background: Concomitant coronary artery disease (CAD) is highly prevalent in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI). The optimal treatment strategy for CAD is a topic of debate. An initial conservative strategy for CAD in patients undergoing TAVI may be favorable as multiple studies have failed to show an evident beneficial effect of percutaneous coronary intervention (PCI) on mortality after TAVI.
View Article and Find Full Text PDFTransCatheter aortic valve implantation and fractional flow reserve-guided percutaneous coronary intervention versus conventional surgical aortic valve replacement and coronary bypass grafting for treatment of patients with aortic valve stenosis and complex or multivessel coronary disease (TCW): an international, multicentre, prospective, open-label, non-inferiority, randomised controlled trial.
Lancet
December 2025
Hôpital haut Lévêque, Unite Médico Chirurgicale, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
Background: Patients with severe aortic stenosis present frequently (∼50%) with concomitant obstructive coronary artery disease. Current guidelines recommend combined surgical aortic valve replacement (SAVR) and coronary artery bypass grafting (CABG) as the preferred treatment. Transcatheter aortic valve implantation (TAVI) and fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) represent a valid treatment alternative.
View Article and Find Full Text PDFTAVI and PCI: redefining treatment for aortic stenosis and complex coronary artery disease.
Lancet
December 2025
Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, 35128 Padova, Italy.
In stable CAD and aortic stenosis, adding routine PCI to TAVI reduced MACE but increased bleeding at 2 y.
Ann Intern Med
December 2024
Health Alliance Hospital, Kingston, New York, USA (E.L.).
Article Synopsis
- The study examines the outcomes of patients who underwent percutaneous coronary intervention (PCI) before undergoing transcatheter aortic valve implantation (TAVI).
- It assesses the impacts of timing and type of PCI on the safety and effectiveness of the TAVI procedure.
- Important findings suggest that proper management of cardiac conditions prior to TAVI can lead to better overall patient outcomes and reduced complications.
TAVI patients with bystander coronary artery disease should receive PCI: pros and cons.
EuroIntervention
November 2024
Cardiovascular Department, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
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