The corn protein zein has several advantages, such as low production cost, excellent biodegradability, good biocompatibility, and low allergenicity. However, the application of zein in the food industry is limited by its high hydrophobicity. To increase the functionality of zein and meet the diverse requirements of food systems, researchers have explored several methods to form complexes or conjugates through noncovalent or covalent interactions, respectively, with polyphenols. This paper comprehensively reviews the formation mechanisms, preparation methods, and influencing factors of zein-polyphenol complexes and conjugates. In addition, the paper presents the techniques used to characterize zein-polyphenol complexes and conjugates and their various new functional properties and bioactivities including water solubility, emulsification activity, in vitro antioxidant activity and antibacterial activity, as well as factors that affect these properties. Furthermore, the potential uses of these compounds in the food sector and future research areas are discussed.
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http://dx.doi.org/10.1016/j.foodchem.2024.142309 | DOI Listing |
Heliyon
January 2025
Pharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Hyaluronic acid (HA) is a popular surface modifier in targeted cancer delivery due to its receptor-binding abilities. However, HA alone faces limitations in lipid solubility, biocompatibility, and cell internalization, making it less effective as a standalone delivery system. This comprehensive study aimed to explore a dynamic landscape of complexation in HA-based nanoparticles in cancer therapy, examining diverse aspects from influential modifiers to emerging trends in cancer diagnostics.
View Article and Find Full Text PDFJ Appl Stat
June 2024
Department of Biostatistics, University of Florida, Gainesville, FL, USA.
Due to the tremendous heterogeneity of disease manifestations, many complex diseases that were once thought to be single diseases are now considered to have disease subtypes. Disease subtyping analysis, that is the identification of subgroups of patients with similar characteristics, is the first step to accomplish precision medicine. With the advancement of high-throughput technologies, omics data offers unprecedented opportunity to reveal disease subtypes.
View Article and Find Full Text PDFACS Sens
January 2025
Department of Chemistry & Biomolecular Science, Clarkson University, Potsdam, New York 13676, United States.
Chloride is the most abundant anion in cells and plays many critical roles in maintaining cellular homeostasis. However, current chloride indicators are rare with inherent sensitivity in their emission properties, such as vulnerability to pH changes or short emission lifetimes. These limitations restrict their application in aqueous media and imaging.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
Conjugation plays a major role in dissemination of antimicrobial resistance genes. Following transfer of IncF-like plasmids, recipients become refractory to a second wave of conjugation with the same plasmid via entry (TraS) and surface (TraT) exclusion mechanisms. Here, we show that TraT from the pKpQIL and F plasmids (TraT and TraT) exhibits plasmid surface exclusion specificity.
View Article and Find Full Text PDFSignal Transduct Target Ther
January 2025
Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Cancers of the digestive system are major contributors to global cancer-associated morbidity and mortality, accounting for 35% of annual cases of cancer deaths. The etiologies, molecular features, and therapeutic management of these cancer entities are highly heterogeneous and complex. Over the last decade, genomic and functional studies have provided unprecedented insights into the biology of digestive cancers, identifying genetic drivers of tumor progression and key interaction points of tumor cells with the immune system.
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