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Biomimetic "Trojan Horse" Fibers Modulate Innate Immunity Cascades for Nerve Regeneration.
ACS Nano
December 2024
Department of Orthopedics, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou 215006, Jiangsu, China.
Neutrophil membrane vesicles (NMVs) have been successfully applied to control the inflammatory cascade after spinal cord injury (SCI) by acting as an inflammatory factor decoy to front-load the overall inflammation regulatory window; however, the mechanisms by which NMVs regulate macrophage phenotypic shifts as well as their outcomes have rarely been reported. In this study, we demonstrated the "efferocytosis-like" effect of NMVs endocytosed by macrophages, supplementing the TCA cycle intermediate metabolite α-KG by promoting glutamine metabolism, which in turn facilitates oxidative phosphorylation and inhibits the NF-κB signaling pathway to reprogram inflammatory macrophages to the pro-regenerative phenotype. Based on these findings, a "Trojan horse" composite fiber scaffold was constructed; this comprised a carboxylated poly-l-lactic acid shell encapsulated with NMVs and a core loaded with brain-derived neurotrophic factor to spatiotemporally modulate the inflammatory microenvironment by 39.
View Article and Find Full Text PDFUnidirectional and sustainable release of NGF and BDNF from a chitosan gel-mediated multilayer ordered composite membrane in promoting both spinal cord and sciatic nerve injury repair.
Int J Biol Macromol
December 2024
College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, PR China. Electronic address:
To develop a scaffold suitable for simultaneous repair of both spinal cord injury (SCI) and sciatic nerve injury (SNI), we designed a multilayer composite membrane capable of unidirectional and sustained release of two factors: nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). The membrane's morphology, mechanical properties, cytocompatibility, drug release kinetics, swelling, and degradation behavior were thoroughly characterized. Additionally, its ability to promote the differentiation of PC-12 cells was assessed.
View Article and Find Full Text PDFThe Clinical Status of Patients With Lumbar Spinal Stenosis Reflects Their Individual Decision to Undergo or Defer Lumbar Spinal Surgery.
J Am Acad Orthop Surg
December 2024
From the Spinal Research Laboratory, Department of Physical Therapy, The Stanley Steyer School of Health Professions, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel (Soroka, Weisman, and Masharawi), the Department of Physical Therapy, Steinhardt School of Culture Education and Human Development, New York University, New York, NY (Lubetzky and Moffat), the Department of Mathematics and Statistics, Dalhousie University, Halifax, Canada (Murphy), the Israel Spine Center, Assuta Hospital, Tel-Aviv, Israel (Ashkenazi and Floman), the Spine Unit, Meir Medical Center, Kfar Saba, Israel (Shabat), and the Department of Orthopedics, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel (Shabat).
Objective: To evaluate whether functional, clinical, and self-reported tests reflect lumbar spinal stenosis patients' decisions to undergo or defer surgery.
Methods: Among 108 participants, 77 chose surgery (SG), and 31 opted to wait and see (WaSG) whether they got better spontaneously. Both groups were assessed at baseline (t0) and 3 months (t1), with additional self-reported measures at 6 (t2) and 12 months (t3).
Open Reduction and Orthogonal Tension Band Plating of an Isolated Periprosthetic Tibial Tubercle Fracture: A Case Report.
JBJS Case Connect
October 2024
Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN.
Case: A 67-year-old woman sustained a periprosthetic tibial tubercle avulsion fracture with extensor mechanism disruption. She underwent open reduction internal fixation (ORIF) with orthogonal mini-fragment plates applied in a tension band fashion with patellar tendon suture augmentation. Radiographs, range of motion, and patient-reported outcomes were completed over 1 year.
View Article and Find Full Text PDFCurrent and future perspectives on pregnancy and lactation-associated osteoporosis.
Front Endocrinol (Lausanne)
December 2024
Section of Endocrinology & Investigative Medicine, Imperial College London, London, United Kingdom.
Normal pregnancy and lactation have a marked physiological impact on maternal bone metabolism. This impact is usually temporary and reversible, but some women sustain fragility fractures whilst pregnant or lactating, termed pregnancy and lactation-associated osteoporosis (PLO). These fractures have severe negative consequences on their quality of life, at what is a crucial stage in a mother's life.
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