Pentatricopeptide repeat proteins in plants: Cellular functions, action mechanisms and potential applications.

Plant Commun

Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao 266237, China. Electronic address:

Published: December 2024

Pentatricopeptide repeat (PPR) proteins are involved in nearly all aspects of post-transcriptional processing in plant mitochondria and plastids, where they play a vital role in plant growth, development, cytoplasmic male sterility (CMS) restoration, and response to biotic and abiotic stresses. Through research in the last three decades, PPR functions and the primary mechanisms by which PPR proteins mediate post-transcriptional processing have been uncovered. Here, we aim to summarize the advances in PPR research with highlighting on the mechanisms of how PPR proteins mediate RNA editing, intron splicing, and RNA maturation in the context of their role in organellar gene expression. We also present the latest progress toward PPR engineering and an outlook for their potential applications as biotechnological tools. Additionally, we discuss further questions that need to be answered.

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http://dx.doi.org/10.1016/j.xplc.2024.101203DOI Listing

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Pentatricopeptide repeat proteins in plants: Cellular functions, action mechanisms and potential applications.

Plant Commun

December 2024

Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao 266237, China. Electronic address:

Pentatricopeptide repeat (PPR) proteins are involved in nearly all aspects of post-transcriptional processing in plant mitochondria and plastids, where they play a vital role in plant growth, development, cytoplasmic male sterility (CMS) restoration, and response to biotic and abiotic stresses. Through research in the last three decades, PPR functions and the primary mechanisms by which PPR proteins mediate post-transcriptional processing have been uncovered. Here, we aim to summarize the advances in PPR research with highlighting on the mechanisms of how PPR proteins mediate RNA editing, intron splicing, and RNA maturation in the context of their role in organellar gene expression.

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