Y. Xu, Y. Gao, Z. Huang, Y. Zheng, W. Teng, D. Zheng, and X. Zheng, "LKB1 Suppresses Androgen Synthesis in a Mouse Model of Hyperandrogenism via IGF-1 Signaling," FEBS Open Bio 9, no. 10 (2019): 1817-1825, https://doi.org/10.1002/2211-5463.12723. The above article, published online on 12 September 2019, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Miguel A. De la Rosa; FEBS Press; and John Wiley and Sons Ltd. The retraction has been agreed upon following an investigation into concerns raised by a third party, which revealed inappropriate image duplications between this (Figure 1C, 1H) and other articles that were previously published or published in the same or following year. Given the extent of the identified issues, the editors have lost confidence in the data presented and consider the conclusions of this manuscript substantially compromised.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/2211-5463.13948 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Athlete Selective Androgen Receptor Modulators Abuse: A Systematic Review.
Am J Sports Med
January 2025
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Background: Selective androgen receptor modulators (SARMs) are small-molecule compounds that exert agonist and antagonist effects on androgen receptors in a tissue-specific fashion. Because of their performance-enhancing implications, SARMs are increasingly abused by athletes. To date, SARMs have no Food and Drug Administration approved use, and recent case reports associate the use of SARMs with deleterious effects such as drug-induced liver injury, myocarditis, and tendon rupture.
View Article and Find Full Text PDFSystems-level liquid biopsy in advanced prostate cancer.
Endocr Relat Cancer
January 2025
S Dehm, Masonic Cancer Center, University of Minnesota, Minneapolis, United States.
Treatment for castration-resistant prostate cancer (CRPC) primarily involves the suppression of androgen receptor (AR) activity using androgen receptor signaling inhibitors (ARSIs). While ARSIs have extended patient survival, resistance inevitably develops. Mechanisms of resistance include genomic aberrations at the AR locus that reactivate AR signaling, or lineage plasticity that drives emergence of AR-independent phenotypes.
View Article and Find Full Text PDFProposing Bromo-epi-androsterone (BEA) for perioperative neurocognitive disorders with Interleukin-6 as a druggable target.
J Clin Anesth
January 2025
Department of Chemistry and Biochemistry, Creighton University, 2500 California Plaza, Omaha, NE 68178, United States of America. Electronic address:
Cognitive impairment following surgery is a significant complication, affecting multiple neurocognitive domains. The term "perioperative neurocognitive disorders" (PND) is recommended to encompass this entity. Individuals who develop PND are typically older and have increases in serum and brain pro-inflammatory cytokines notwithstanding the type of surgery undergone.
View Article and Find Full Text PDFDysregulated LINC01133 expression in laryngeal carcinoma: Prognostic implications and predicted ceRNA interactome.
Mol Biol Res Commun
January 2025
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- LINC01133 is a long non-coding RNA (lncRNA) that plays crucial roles in cancer, with this study focusing on its expression and impact in laryngeal squamous cell carcinoma (LSCC).
- Integrative analysis of genetic data revealed LINC01133 is significantly downregulated in LSCC compared to normal tissues, and lower levels are linked to advanced tumor stages and lymph node metastasis.
- The study suggests that LINC01133 may act as a tumor suppressor by disrupting microRNA interactions, indicating its potential diagnostic and therapeutic importance in LSCC.
LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer.
Cell Res
January 2025
Key Laboratory of Multi-Cell Systems, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
Article Synopsis
- Epigenetic regulation significantly affects cancer cell behavior and their ability to adapt, influencing tumor diversity and treatment outcomes.
- In castration-resistant prostate cancer (CRPC), the mechanisms behind tumor cells becoming independent of androgen receptors (AR) are not well understood, contributing to a lack of effective therapies.
- Research using advanced single-cell RNA sequencing revealed that the loss of the LKB1 pathway is linked to AR independence, leading to changes in gene expression and DNA modification patterns, suggesting that targeting DNA hypomethylation could be a promising therapy for AR-independent CRPC.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!