AI Article Synopsis
- Extracellular vesicles (EVs) are membrane-bound structures released by brain cells, playing an increasingly recognized role in neurodegenerative diseases.
- Research has shifted from basic biology of EVs to their clinical applications, particularly in identifying biomarkers and therapeutic targets for these diseases.
- The review discusses the characteristics, functions, and biological mechanisms of different types of brain-derived EVs, along with potential therapeutic strategies and challenges in using EVs for drug delivery.
Article Abstract
Extracellular vesicles (EVs) are membrane vesicles originating from different cells within the brain. The pathophysiological role of EVs in neurodegenerative diseases is progressively acknowledged. This field has advanced from basic biological research to essential clinical significance. The capacity to selectively enrich specific subsets of EVs from biofluids via distinctive surface markers has opened new avenues for molecular understandings across various tissues and organs, notably in the brain. In recent years, brain-derived EVs have been extensively investigated as biomarkers, therapeutic targets, and drug-delivery vehicles for neurodegenerative diseases. This review provides a brief overview of the characteristics and physiological functions of the various classes of EVs, focusing on the biological mechanisms by which various types of brain-derived EVs mediate the occurrence and development of neurodegenerative diseases. Concurrently, novel therapeutic approaches and challenges for the use of EVs as delivery vehicles are delineated.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622582 | PMC |
| http://dx.doi.org/10.1186/s40035-024-00453-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!