Objective: Analyze data from a 15-year longitudinal study of search-and-rescue (SAR) dogs to determine the indications for surgery and evaluate whether the risk varied by breed, sex, neutering, or deployment status during 9/11.
Methods: 150 SAR dogs: 95 dogs deployed to sites from the September 11, 2001, terrorist attacks and 55 SAR dogs not deployed to these sites. Search-and-rescue dog handlers completed an annual health survey until the dog's death, or the handler withdrew from the study. The reported surgical events were categorized by body system and etiology. Incidence risk rates, with 95% CIs, were calculated for the most common surgical indications. Incidence rate ratios were calculated stratified by deployment status, sex, and breed, and significance was assessed.
Results: Over the study period, 103 surgical events were recorded in 67 of the 150 dogs (45%; 95% CI, 37% to 53%); 41 dogs had 1 event, 18 had 2 events, 6 had 3 events, and 2 had 4 events. Deployment status during 9/11, breed, sex, and neuter status were not significantly associated with the affected body system.
Conclusions: The most affected body systems were the integumentary and musculoskeletal systems. The most common etiologies were trauma, neoplasia, inflammatory, and degenerative conditions. Search-and-rescue dogs experienced relatively routine or minor conditions despite the occupational hazards of their careers.
Clinical Relevance: Surgery will impact working dog health and performance. Preventive efforts to reduce and interventions to treat surgical conditions in SAR dogs should focus on the integumentary and musculoskeletal systems.
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http://dx.doi.org/10.2460/javma.24.09.0587 | DOI Listing |
J Med Chem
December 2024
Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, P. R. China.
Inspired by our previous finding that targeting the 150-cavity with a multisite-binding strategy emerged as an effective approach to obtain more potent and selective neuraminidase (NA) inhibitors against influenza virus, we present here the design, synthesis, and optimization of novel boron-containing N-substituted oseltamivir (OSC) derivatives. Exploratory structure-activity relationship (SAR) studies led to the identification of compounds and as the most potent NA inhibitors, surpassing OSC in potency against both wild-type group-1 NAs and oseltamivir-resistant NAs. These compounds demonstrated significant antiviral activity against several wild-type strains and H1N1pdm09 strains (EC = 0.
View Article and Find Full Text PDFJ Am Vet Med Assoc
December 2024
2Penn Vet Working Dog Center, Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA.
Objective: Analyze data from a 15-year longitudinal study of search-and-rescue (SAR) dogs to determine the indications for surgery and evaluate whether the risk varied by breed, sex, neutering, or deployment status during 9/11.
Methods: 150 SAR dogs: 95 dogs deployed to sites from the September 11, 2001, terrorist attacks and 55 SAR dogs not deployed to these sites. Search-and-rescue dog handlers completed an annual health survey until the dog's death, or the handler withdrew from the study.
PLoS Pathog
December 2024
College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
Raccoon dog was proposed as a potential host of SARS-CoV-2, but no evidence support such a notion. In our study, we investigated the binding affinities of raccoon dog ACE2 (rdACE2) to the spike (S) protein receptor binding domain (RBD) of SARS-CoV-2 prototype (PT) and its variants. It revealed that the binding affinities of RBD from SARS-CoV-2 variants were generally lower than that of the PT RBD.
View Article and Find Full Text PDFParasit Vectors
November 2024
Department of Veterinary Clinical Sciences, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China.
Background: Dirofilaria sp. "hongkongensis" is a putative Dirofilaria species, initially identified in subcutaneous nodules in humans in Hong Kong and in other South and Southeast Asian regions. While it differs genetically from the better-known zoonotic species, Dirofilaria repens and Dirofilaria immitis, information on the lesions caused by Dirofilaria sp.
View Article and Find Full Text PDFFront Vet Sci
October 2024
Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Identifying risk factors associated with the carriage of antimicrobial-resistant (AMR) bacteria in dogs is crucial to understanding their epidemiology and for developing and refining targeted control measures. However, relevant data is scattered and conflicting findings have been reported. This systematic review aimed to compile risk factors associated with the carriage of AMR- in dogs worldwide and to identify relevant knowledge gaps for directing future research.
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